ArticleInternational journal of nanomedicine2017
Toxicity studies of six types of carbon nanoparticles in a chicken-embryo model.
Article in International journal of nanomedicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Iron nanoparticles - biodistribution in the chicken embryo model.Biochemistry and biophysics reports · 2026Article
- Evaluation of the Dual Impact of Nanotechnologies on Health and Environment Through Alternative Bridging Models.Advanced healthcare materials · 2026Review
- Methodological and Ethical Considerations in the Use of Chordate Embryos in Biomedical Research.International journal of molecular sciences · 2025Review
- Chicken embryo model forInternational journal of pharmaceutics: X · 2023Article
- Applied Methods to Assess the Antimicrobial Activity of Metallic-Based Nanoparticles.Bioengineering (Basel, Switzerland) · 2023Article
- Graphene Oxide Decreases Pro-Inflammatory Proteins Production in Skeletal Muscle Cells Exposed to SARS-CoV-2 Spike Protein.Nanotechnology, science and applications · 2023Article
- Reproductive and Developmental Nanotoxicity of Carbon Nanoparticles.Nanomaterials (Basel, Switzerland) · 2022Review
- Physiological Changes in Chicken Embryos Inoculated with Drugs and Viruses Highlight the Need for More Standardization of this Animal Model.Animals : an open access journal from MDPI · 2022Article
- Sources and levels of copper affect liver copper profile, intestinal morphology and cecal microbiota population of broiler chickens fed wheat-soybean meal diets.Scientific reports · 2022Article
- Comprehensive Approaches of Nanoparticles for Growth Performance and Health Benefits in Poultry: An Update on the Current Scenario.BioMed research international · 2022Review
- Quantum Point Defects for Solid-State Laser Refrigeration.Advanced materials (Deerfield Beach, Fla.) · 2021Review
- The chicken embryo as an in vivo experimental model for drug testing: Advantages and limitations.Lab animal · 2021Article
- Toxicity of Carbon, Silicon, and Metal-Based Nanoparticles to Sea Urchin Strongylocentrotus Intermedius.Nanomaterials (Basel, Switzerland) · 2020Article
- Developmental toxicity of carbon nanoparticles during embryogenesis in chicken.Environmental science and pollution research international · 2020Review
- Single-walled carbon nanotubes loaded hydroxyapatite-alginate beads with enhanced mechanical properties and sustained drug release ability.Progress in biomaterials · 2020Article
- Nanoparticle-Based Devices in the Control of Antibiotic Resistant Bacteria.Frontiers in microbiology · 2020Review
- Influence of Selected Carbon Nanostructures on the CYP2C9 Enzyme of the P450 Cytochrome.Materials (Basel, Switzerland) · 2019Article
- Impairment of the immune response after transcuticular introduction of the insect gonadoinhibitory and hemocytotoxic peptide Neb-colloostatin: A nanotech approach for pest control.Scientific reports · 2019Article
- Embryonic Chicken (Comparative medicine · 2019Review
- Particle toxicology and health - where are we?Particle and fibre toxicology · 2019Review
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the present study, the toxicity of six different types of carbon nanoparticles (CNPs) was investigated using a chicken-embryo model. Fertilized chicken eggs were divided into the following treatment groups: placebo, diamond NPs, graphite NPs, pristine graphene, small graphene oxide, large graphene oxide, and reduced graphene oxide. Experimental solutions at a concentration of 500 μg/mL were administrated into the egg albumin. Gross pathology and the rate of survival were examined after 5, 10, 15, and 20 days of incubation. After 20 days of incubation, blood samples were collected and the weight of the body and organs measured. The relative ratio of embryo survival decreased after treatment all treatments except diamond NPs. There was no correlation between the rate of survival and the ζ-potential or the surface charge of the CNPs in solution. Body and organ weight, red blood-cell morphology, blood serum biochemical parameters, and oxidative damage in the liver did not differ among the groups. These results indicate that CNPs can remain in blood circulation without any major side effects, suggesting their potential applicability as vehicles for drug delivery or active compounds per se. However, there is a need for further investigation of their properties, which vary depending on production methods and surface functionalization.
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