ArticleClinical interventions in aging2017
Age-based model for metacarpophalangeal joint proprioception in elderly.
Article in Clinical interventions in aging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 19 citations in OpenAlex.
- Reliability, validity, and clinical feasibility of a rapid and objective assessment of post-stroke deficits in hand proprioception.Journal of neuroengineering and rehabilitation · 2018Trial
- The Evolution of Hand Proprioceptive and Motor Impairments in the Sub-Acute Phase After Stroke.Neurorehabilitation and neural repair · 2023Article
- Aging increases proprioceptive error for a broad range of movement speed and distance estimates in the upper limb.Frontiers in human neuroscience · 2023Article
- Reliable and Valid Robotic Assessments of Hand Active and Passive Position Sense in Children With Unilateral Cerebral Palsy.Frontiers in human neuroscience · 2022Article
- Age-Dependent Asymmetry of Wrist Position Sense Is Not Influenced by Stochastic Tactile Stimulation.Frontiers in human neuroscience · 2020Article
- A data-driven framework for selecting and validating digital health metrics: use-case in neurological sensorimotor impairments.NPJ digital medicine · 2020Article
- Temporal Discrimination Thresholds and Proprioceptive Performance: Impact of Age and Nerve Conduction.Frontiers in neuroscience · 2019Article
- Quantification of upper limb position sense using an exoskeleton and a virtual reality display.Journal of neuroengineering and rehabilitation · 2018Article
- Enhancing simulations with intra-subject variability for improved psychophysical assessments.PloS one · 2018Article
- Performance metrics for an application-driven selection and optimization of psychophysical sampling procedures.PloS one · 2018Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neurological injuries such as stroke can lead to proprioceptive impairment. For an informed diagnosis, prognosis, and treatment planning, it is essential to be able to distinguish between healthy performance and deficits following the neurological injury. Since there is some evidence that proprioception declines with age and stroke occurs predominantly in the elderly population, it is important to create a healthy reference model in this specific age group. However, most studies investigate age effects by comparing young and elderly subjects and do not provide a model within a target age range. Moreover, despite the functional relevance of the hand in activities of daily living, age-based models of distal proprioception are scarce. Here, we present a proprioception model based on the assessment of the metacarpophalangeal joint angle difference threshold in 30 healthy elderly subjects, aged 55-80 years (median: 63, interquartile range: 58-66), using a robotic tool to apply passive flexion-extension movements to the index finger. A two-alternative forced-choice paradigm combined with an adaptive algorithm to define stimulus magnitude was used. The mixed-effects model analysis revealed that aging has a significant, increasing effect on the difference threshold at the metacarpophalangeal joint, whereas other predictors (eg, tested hand or sex) did not show a significant effect. The adaptive algorithm allowed reaching an average assessment duration <15 minutes, making its clinical applicability realistic. This study provides further evidence for an age-related decline in proprioception at the level of the hand. The established age-based model of proprioception in elderly may serve as a reference model for the proprioceptive performance of stroke patients, or of any other patient group with central or peripheral proprioceptive impairments. Furthermore, it demonstrates the potential of such automated robotic tools as a rapid and quantitative assessment to be used in research and clinical settings.
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