ReviewNature reviews. Nephrology2017
The systemic nature of CKD.
Review in Nature reviews. Nephrology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 274 papers, 8 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
274 citing papers in PubMed, 8 syntheses or guidelines pooled it.
- Effects of Exercise Training on Experimental Chronic Kidney Disease: A Systematic Review and Meta-Analysis.International journal of molecular sciences · 2026Pooled it
- Oligoprotein type I interferon signatures, but not TREX1 variants, increase risk of systemic lupus erythematosus in UK Biobank.Nature communications · 2026Pooled it
- The effect of exercise training on quality of life in people with chronic kidney disease requiring dialysis. A systematic review with meta-analysis.Journal of nephrology · 2025Pooled it
- Sleep disturbances in adults with chronic kidney disease: an umbrella review.Journal of nephrology · 2025Pooled it
- Efficacy of probiotics/synbiotics supplementation in patients with chronic kidney disease: a systematic review and meta-analysis of randomized controlled trials.Frontiers in nutrition · 2024Pooled it
- Gastrointestinal bleeding in chronic kidney disease patients: a systematic review and meta-analysis.Renal failure · 2023Pooled it
- Increased soluble urokinase plasminogen activator levels modulate monocyte function to promote atherosclerosis.The Journal of clinical investigation · 2022Pooled it
- Pooled it
- Pharmacokinetics, Elimination and Dialyzability of HRS-9231 in Patients with Varying Degrees of Renal Impairment.Clinical pharmacokinetics · 2026Article
- NLRP3 Inflammasome Activation and Atherogenic Lipid Profile in Hemodialysis Patients.Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy · 2026Article
- Mechanisms of regeneration and maladaptive repair in acute kidney injury.Nature reviews. Nephrology · 2026Review
- Association between allostatic load and chronic kidney disease: findings from the NHANES 2015-2018 study.International urology and nephrology · 2026Article
- Experimental rodent models of cardiorenal syndrome types 3 and 4: Insights and clinical relevance (Review).International journal of molecular medicine · 2026Review
- Review
- Texture Analysis of Multiparametric Kidney MRI-A Non-Invasive Approach to Chronic Kidney Disease State.Biomedicines · 2026Article
- Association of E-Selectin with Inflammation, Mineral and Bone Disorder, and Endothelial Dysfunction in Hemodialysis Patients.International journal of molecular sciences · 2026Article
- Investigation of the cortical bone metabolome of C57BL/6J mice with adenine-induced kidney disease.JBMR plus · 2026Article
- Impact of Improved End-Stage Renal Disease Patient Survival on Prosthetic Valve Selection in Aortic Valve Replacement: A Nationwide Cohort Analysis.Journal of clinical medicine · 2026Article
- Breath ammonia test for chronic kidney disease screening: impact of fasting on diagnostic accuracy.Clinical kidney journal · 2026Article
- Urinary macrophage migration inhibitory factor predicts kidney failure in advanced CKD patients.BMC nephrology · 2026Article
214 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The accurate definition and staging of chronic kidney disease (CKD) is one of the major achievements of modern nephrology. Intensive research is now being undertaken to unravel the risk factors and pathophysiologic underpinnings of this disease. In particular, the relationships between the kidney and other organs have been comprehensively investigated in experimental and clinical studies in the last two decades. Owing to technological and analytical limitations, these links have been studied with a reductionist approach focusing on two organs at a time, such as the heart and the kidney or the bone and the kidney. Here, we discuss studies that highlight the complex and systemic nature of CKD. Energy balance, innate immunity and neuroendocrine signalling are highly integrated biological phenomena. The diseased kidney disrupts such integration and generates a high-risk phenotype with a clinical profile encompassing inflammation, protein-energy wasting, altered function of the autonomic and central nervous systems and cardiopulmonary, vascular and bone diseases. A systems biology approach to CKD using omics techniques will hopefully enable in-depth study of the pathophysiology of this systemic disease, and has the potential to unravel critical pathways that can be targeted for CKD prevention and therapy.
Indexed as
Identifiers
28435157What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.