ArticleStem cell reports2017
iPSC-Derived Regulatory Dendritic Cells Inhibit Allograft Rejection by Generating Alloantigen-Specific Regulatory T Cells.
Article in Stem cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 41 citations in OpenAlex.
- Induced pluripotent stem cell-derived dendritic cells potentiate the efficacy of interleukin-12-expressing oncolytic HSV-1.Molecular therapy. Oncology · 2026Article
- Immune modulation in transplant medicine: a comprehensive review of cell therapy applications and future directions.Frontiers in immunology · 2024Review
- Exploring the promising potential of induced pluripotent stem cells in cancer research and therapy.Molecular cancer · 2023Review
- Noninvasive quantification of granzyme B in cardiac allograft rejection using targeted ultrasound imaging.Frontiers in immunology · 2023Article
- Sinomenine promotes differentiation of induced pluripotent stem cells into immature dendritic cells with high induction of immune tolerance.World journal of stem cells · 2022Article
- Efficacy of an ALDH peptide-based dendritic cell vaccine targeting cancer stem cells.Cancer immunology, immunotherapy : CII · 2022Article
- Article
- Immunological considerations and challenges for regenerative cellular therapies.Communications biology · 2021Review
- Human DC3 Antigen Presenting Dendritic Cells From Induced Pluripotent Stem Cells.Frontiers in cell and developmental biology · 2021Article
- The Role of Regulatory Myeloid Cell Therapy in Renal Allograft Rejection.Frontiers in immunology · 2021Review
- The Immune-Modulatory Properties of iPSC-Derived Antigen-Presenting Cells.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2020Review
- An analysis of monocytes and dendritic cells differentiated from human peripheral blood monocyte-derived induced pluripotent stem cells.Medical molecular morphology · 2020Article
- Manufacturing Dendritic Cells for Immunotherapy: Monocyte Enrichment.Molecular therapy. Methods & clinical development · 2020Review
- Immune reaction and regulation in transplantation based on pluripotent stem cell technology.Inflammation and regeneration · 2020Review
- Manipulation of Regulatory Dendritic Cells for Induction Transplantation Tolerance.Frontiers in immunology · 2020Review
- Monotherapy With Anti-CD70 Antibody Causes Long-Term Mouse Cardiac Allograft Acceptance With Induction of Tolerogenic Dendritic Cells.Frontiers in immunology · 2020Article
- Tolerogenic Dendritic Cells: The Pearl of Immunotherapy in Organ Transplantation.Frontiers in immunology · 2020Review
- Regulatory dendritic cells: profiling, targeting, and therapeutic application.Current opinion in organ transplantation · 2018Review
- The immune response is a prerequisite for the development of CD4International journal of clinical and experimental pathology · 2018Article
- Acute Myeloid Leukemia Cells Express ICOS Ligand to Promote the Expansion of Regulatory T Cells.Frontiers in immunology · 2018Article
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Regulatory dendritic cell (DCregs)-based immunotherapy is a potential therapeutic tool for transplant rejection. We generated DCregs from murine induced pluripotent stem cells (iPSCs), which could remain in a "stable immature stage" even under strong stimulation. Harnessing this characteristic, we hypothesized that iPS-DCregs worked as a negative vaccine to generate regulatory T cells (Tregs), and induced donor-specific allograft acceptance. We immunized naive CBA (H-2K
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Registered trials
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