Evidence map›Paper›PMID 28434940›Full record

ArticleStem cell reports2017

Prospective Isolation and Comparison of Human Germinal Matrix and Glioblastoma EGFR

Jessica Tome-Garcia, Rut Tejero, German Nudelman, Raymund L Yong, Robert Sebra, Huaien Wang, Mary Fowkes, Margret Magid, Martin Walsh, Violeta Silva-Vargas and 4 more

Abstract read
In one paragraph

Article in Stem cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jessica Tome-GarciaDepartment of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Neuroscience, Friedman Brain Institute, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Rut TejeroDepartment of Neuroscience, Friedman Brain Institute, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
German NudelmanDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Raymund L YongDepartment of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Robert SebraDepartment of Pharmacological Sciences, Center for RNA Biology and Medicine and Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Huaien WangDepartment of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Mary FowkesDepartment of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Margret MagidDepartment of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Martin WalshDepartment of Pharmacological Sciences, Center for RNA Biology and Medicine and Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Violeta Silva-VargasDepartment of Pathology and Cell Biology, Columbia University Medical Center, New York, NY 10032, USA; Biozentrum, University of Basel, Basel 4056, Switzerland.
Elena ZaslavskyDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Roland H FriedelDepartment of Neuroscience, Friedman Brain Institute, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Fiona DoetschDepartment of Pathology and Cell Biology, Columbia University Medical Center, New York, NY 10032, USA; Biozentrum, University of Basel, Basel 4056, Switzerland.
Nadejda M TsankovaDepartment of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Neuroscience, Friedman Brain Institute, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: nadejda.tsankova@mssm.edu.

Funding

THE TISCH CANCER INSTITUTE - CANCER CENTER SUPPORT GRANTP30CA196521 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Deanna L Benson · 2015 to 2026
$35.4M
Plexin-B2 function in glioma invasion and glioma stem cell maintenanceR01NS092735 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI FRIEDEL, ROLAND HORST · 2016 to 2025
$4.1M
Prospective Purification of Adult Stem Cell AstrocytesR01NS074039 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SHELANSKI, MICHAEL L · 2011 to 2015
$1.7M
NCI NIH HHS P30 CA196521NINDS NIH HHS R01 NS074039NINDS NIH HHS R01 NS092735
6 · The paper itself

Abstract

Characterization of non-neoplastic and malignant human stem cell populations in their native state can provide new insights into gliomagenesis. Here we developed a purification strategy to directly isolate EGFR

Indexed as

Cell ProliferationAnimalsBrain NeoplasmsCells, CulturedCell SeparationErbB ReceptorsGlioblastomaHumansMaleMice, SCIDNeoplastic Stem CellsNeural Stem CellsPrimary Cell CultureTranscriptomeXenograft Model Antitumor AssaysEGFR protein, humanErbB ReceptorsEGFRFACSgerminal matrixglioblastomaglioma stem cellsneural stem cellsneurosphereRNA-seqtranscriptometumor initiation

Identifiers

PMID28434940
PMCPMC5425658

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.