ArticleBrain, behavior, and immunity2017
Maternal socioeconomic disadvantage is associated with transcriptional indications of greater immune activation and slower tissue maturation in placental biopsies and newborn cord blood.
Article in Brain, behavior, and immunity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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Who cites it
42 citing papers in PubMed, 63 citations in OpenAlex.
- Inflammatory markers in serum and placenta in a randomized controlled trial of group prenatal care.American journal of obstetrics & gynecology MFM · 2023Trial
- The impact of gestational diabetes mellitus on mid-pregnancy and infant cardiac morphology and function: A prospective cohort study.The Journal of international medical research · 2026Article
- DNA methylation in the placenta and household socioeconomic status: the SPAH study.Clinical epigenetics · 2026Article
- Implications for the Prevention of Poverty-Related Environmental Risks for Childhood ADHD: A Narrative Review.Child psychiatry and human development · 2026Review
- Correction: Implications for the Prevention of Poverty-Related Environmental Risks for Childhood ADHD: A Narrative Review.Child psychiatry and human development · 2026Article
- Associations of multiple dimensions of socioeconomic status with adverse pregnancy outcomes.Pregnancy (Hoboken, N.J.) · 2025Article
- Spatial metabolomics and transcriptomics reveal cell type-specific dynamics in the placenta of patients with late-onset preeclampsia.Frontiers in cell and developmental biology · 2025Article
- Molecular connections between inflammation and social determinants of health.Frontiers in epidemiology · 2025Review
- Associations Between Prenatal Vitamin D and Placental Gene Expression.The Journal of nutrition · 2024Article
- Lower Socioeconomic Status Predicts Increased Proinflammatory Signaling in Late Pregnancy: Evidence From a Filipino Cohort.American journal of human biology : the official journal of the Human Biology Council · 2024Article
- Associations Between Prenatal Vitamin D and Placental Gene Expression.bioRxiv : the preprint server for biology · 2024Article
- Associations of maternal stress, gene expression, and newborn birthweight in the Democratic Republic of Congo.American journal of biological anthropology · 2024Article
- Prenatal mood and anxiety disorders and associated cytokine changes.Journal of affective disorders · 2024Article
- Prenatal exposure to maternal disadvantage-related inflammatory biomarkers: associations with neonatal white matter microstructure.Translational psychiatry · 2024Article
- A role for adverse childhood experiences and depression in preeclampsia.Journal of clinical and translational science · 2024Article
- Fetal CCL2 signaling mediates offspring social behavior and recapitulates effects of prenatal stress.Brain, behavior, and immunity · 2024Article
- Adaptation of Screening Tools for Social Determinants of Health in Pregnancy: A Pilot Project.Maternal and child health journal · 2023Article
- Association between prenatal socioeconomic disadvantage, adverse birth outcomes, and inflammatory response at birth.Psychoneuroendocrinology · 2023Article
- Inflammation and the Potential Implication of Macrophage-Microglia Polarization in Human ASD: An Overview.International journal of molecular sciences · 2023Review
- Maternal immune activation as an epidemiological risk factor for neurodevelopmental disorders: Considerations of timing, severity, individual differences, and sex in human and rodent studies.Frontiers in neuroscience · 2023Review
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 1 country.
Funding
Abstract
Children from economically disadvantaged families experience worse cognitive, psychiatric, and medical outcomes compared to more affluent youth. Preclinical models suggest some of the adverse influence of disadvantage could be transmitted during gestation via maternal immune activation, but this hypothesis has not been tested in humans. It also remains unclear whether prenatal interventions can mitigate such effects. To fill these gaps, we conducted two studies. Study 1 characterized the socioeconomic conditions of 79 women during pregnancy. At delivery, placenta biopsies and umbilical blood were collected for transcriptional profiling. Maternal disadvantage was associated with a transcriptional profile indicative of higher immune activation and slower fetal maturation, particularly in pathways related to brain, heart, and immune development. Cord blood cells of disadvantaged newborns also showed indications of immaturity, as reflected in down-regulation of pathways that coordinate myeloid cell development. These associations were independent of fetal sex, and characteristics of mothers (age, race, adiposity, diabetes, pre-eclampsia) and babies (delivery method, gestational age). Study 2 performed the same transcriptional analyses in specimens from 20 women participating in CenteringPregnancy, a group-based psychosocial intervention, and 20 women in traditional prenatal care. In both placenta biopsies and cord blood, women in CenteringPregnancy showed up-regulation of transcripts found in Study 1 to be most down-regulated in conjunction with disadvantage. Collectively, these results suggest socioeconomic disparities in placental biology are evident at birth, and provide clues about the mechanistic origins of health disparities. They also suggest the possibility that psychosocial interventions could have mitigating influences.
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