ArticleDevelopmental biology2017
Genetic dissection of the planarian reproductive system through characterization of Schmidtea mediterranea CPEB homologs.
Article in Developmental biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 39 citations in OpenAlex.
- Drift of positional identity drives reproductive aging in a long-lived regenerative animal.Current biology : CB · 2026Article
- A male-pheromone-elevated transcription factor ZNF362.1 in female schistosomes determines sexual maturation.Science advances · 2026Article
- A Tousled-like kinase (TLK) homolog required for male germline stem cell homeostasis in the planarian Schmidtea mediterranea.Developmental biology · 2026Article
- Article
- Regeneration leads to global tissue rejuvenation in aging sexual planarians.Nature aging · 2025Article
- Melastatin family Transient Receptor Potential channels support spermatogenesis in planarian flatworms.The International journal of developmental biology · 2025Article
- Exploring the potential ofCurrent research in toxicology · 2025Article
- A niche-derived nonribosomal peptide triggers planarian sexual development.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- A niche-derived non-ribosomal peptide triggers planarian sexual development.bioRxiv : the preprint server for biology · 2023Article
- Cytoplasmic Polyadenylation Is an Ancestral Hallmark of Early Development in Animals.Molecular biology and evolution · 2023Article
- Article
- Whole-Mount In Situ Hybridization in Large Sexual Schmidtea mediterranea.Methods in molecular biology (Clifton, N.J.) · 2023Article
- A Krüppel-like factor is required for development and regeneration of germline and yolk cells from somatic stem cells in planarians.PLoS biology · 2022Article
- Article
- Somatic regulation of female germ cell regeneration and development in planarians.Cell reports · 2022Article
- Identification of novel yolk ferritins unique to planarians: planarians supply aluminum rather than iron to vitellaria in egg capsules.Cell and tissue research · 2021Article
- Heterotrimeric Kinesin II is required for flagellar assembly and elongation of nuclear morphology during spermiogenesis in Schmidtea mediterranea.Developmental biology · 2021Article
- Regeneration in starved planarians depends on TRiC/CCT subunits modulating the unfolded protein response.EMBO reports · 2021Article
- Regeneration of Planarian Auricles and Reestablishment of Chemotactic Ability.Frontiers in cell and developmental biology · 2021Article
- Dynein assembly factor with WD repeat domains 1 (DAW1) is required for the function of motile cilia in the planarian Schmidtea mediterranea.Development, growth & differentiation · 2020Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Cytoplasmic polyadenylation is a mechanism of mRNA regulation prevalent in metazoan germ cells; it is largely dependent on Cytoplasmic Polyadenylation Element Binding proteins (CPEBs). Two CPEB homologs were identified in the planarian Schmidtea mediterranea. Smed-CPEB1 is expressed in ovaries and yolk glands of sexually mature planarians, and required for oocyte and yolk gland development. In contrast, Smed-CPEB2 is expressed in the testes and the central nervous system; its function is required for spermatogenesis as well as non-autonomously for development of ovaries and accessory reproductive organs. Transcriptome analysis of CPEB knockdown animals uncovered a comprehensive collection of molecular markers for reproductive structures in S. mediterranea, including ovaries, testes, yolk glands, and the copulatory apparatus. Analysis by RNA interference revealed contributions for a dozen of these genes during oogenesis, spermatogenesis, or capsule formation. We also present evidence suggesting that Smed-CPEB2 promotes translation of Neuropeptide Y-8, a prohormone required for planarian sexual maturation. These findings provide mechanistic insight into potentially conserved processes of germ cell development, as well as events involved in capsule deposition by flatworms.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.