ArticleNeuron2017
Medial Entorhinal Cortex Selectively Supports Temporal Coding by Hippocampal Neurons.
Article in Neuron, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
64 citing papers in PubMed.
- Decoding Medial Entorhinal Cortical Dynamics Produces Planning-Like Alternations in Hippocampal theta Sequences.Hippocampus · 2026Article
- Clustered inputs engage dendritic nonlinearities and calcium signaling to support efficient place-field formation in CA1 pyramidal neurons.Cell reports · 2026Article
- Impaired spatial coding and neuronal hyperactivity in the medial entorhinal cortex of aged APP knock-in mice.Cell reports · 2026Article
- Coordinating Cognition: The Entorhinal Cortex in Mnemonic, Temporal and Spatial Representation.Cells · 2026Review
- Temporal Coding rather than Circuit Wiring allows Hippocampal CA3 Neurons to Dynamically Distinguish Different Cortical Inputs.bioRxiv : the preprint server for biology · 2026Article
- Time or distance encoding by hippocampal neurons via heterogeneous ramping rates.Nature communications · 2025Article
- Effective computations for hippocampal place cell phenomena in sparse untrained random networks.bioRxiv : the preprint server for biology · 2025Article
- Allothetic and idiothetic spatial cues control the multiplexed theta phase coding of place cells.Nature neuroscience · 2025Article
- Article
- Time cell sequences during delay intervals are not dependent on brain state and do not support hippocampus-dependent working memory.Nature communications · 2025Article
- Article
- Theta phase precession supports memory formation and retrieval of naturalistic experience in humans.Nature human behaviour · 2024Article
- Remapping revisited: how the hippocampus represents different spaces.Nature reviews. Neuroscience · 2024Review
- Direct cortical inputs to hippocampal area CA1 transmit complementary signals for goal-directed navigation.Neuron · 2023Article
- Temporal encoding in deep reinforcement learning agents.Scientific reports · 2023Article
- A neural code for time and space in the human brain.Cell reports · 2023Article
- Associative and predictive hippocampal codes support memory-guided behaviors.Science (New York, N.Y.) · 2023Article
- Dissecting cell-type-specific pathways in medial entorhinal cortical-hippocampal network for episodic memory.Journal of neurochemistry · 2023Review
- Rat hippocampal CA1 region represents learning-related action and reward events with shorter latency than the lateral entorhinal cortex.Communications biology · 2023Article
- Optogenetic frequency scrambling of hippocampal theta oscillations dissociates working memory retrieval from hippocampal spatiotemporal codes.Nature communications · 2023Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Recent studies have shown that hippocampal "time cells" code for sequential moments in temporally organized experiences. However, it is currently unknown whether these temporal firing patterns critically rely on upstream cortical input. Here we employ an optogenetic approach to explore the effect of large-scale inactivation of the medial entorhinal cortex on temporal, as well as spatial and object, coding by hippocampal CA1 neurons. Medial entorhinal inactivation produced a specific deficit in temporal coding in CA1 and resulted in significant impairment in memory across a temporal delay. In striking contrast, spatial and object coding remained intact. Further, we extended the scope of hippocampal phase precession to include object information relevant to memory and behavior. Overall, our work demonstrates that medial entorhinal activity plays an especially important role for CA1 in temporal coding and memory across time.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.