Trial reportRadiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology2017
Prognostic value of dynamic hypoxia PET in head and neck cancer: Results from a planned interim analysis of a randomized phase II hypoxia-image guided dose escalation trial.
Trial report in Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.
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53 citing papers in PubMed, 1 synthesis or guideline pooled it, 121 citations in OpenAlex.
- What is the prognostic impact of FDG PET in locally advanced head and neck squamous cell carcinoma treated with concomitant chemo-radiotherapy? A systematic review and meta-analysis.European journal of nuclear medicine and molecular imaging · 2018Pooled it
- Trial
- Interleukin-6 as surrogate marker for imaging-based hypoxia dynamics in patients with head-and-neck cancers undergoing definitive chemoradiation-results from a prospective pilot trial.European journal of nuclear medicine and molecular imaging · 2022Trial
- Lymphocyte Infiltration Determines the Hypoxia-Dependent Response to Definitive Chemoradiation in Head-and-Neck Cancer: Results from a Prospective Imaging Trial.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2021Trial
- Report on planning comparison of VMAT, IMRT and helical tomotherapy for the ESCALOX-trial pre-study.Radiation oncology (London, England) · 2020Trial
- Correlative analyses between tissue-based hypoxia biomarkers and hypoxia PET imaging in head and neck cancer patients during radiochemotherapy-results from a prospective trial.European journal of nuclear medicine and molecular imaging · 2020Trial
- Trial
- Prospective Evaluation of a Tumor Control Probability Model Based on DynamicJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2019Trial
- Trial
- Repeatability of tumour hypoxia imaging using [European journal of nuclear medicine and molecular imaging · 2018Trial
- DWI-guided DP-IMRT and conventional MRI-based IMRT in head and neck squamous cell carcinoma: a comparative study.BMC cancer · 2025Article
- Imaging hypoxia for head and neck cancer: current status, challenges, and prospects.Theranostics · 2025Review
- Tumor Hypoxia on 18F-fluoromisonidazole Positron Emission Tomography and Distant Metastasis From Head and Neck Squamous Cell Carcinoma.JAMA network open · 2024Article
- Role ofCancers · 2024Review
- Combined RBE and OER optimization in proton therapy with FLUKA based on EF5-PET.Journal of applied clinical medical physics · 2023Article
- Machine learning identifies multi-parametric functional PET/MR imaging cluster to predict radiation resistance in preclinical head and neck cancer models.European journal of nuclear medicine and molecular imaging · 2023Article
- Article
- Dose escalation in oropharyngeal cancer: a comparison of simultaneous integrated boost and brachytherapy boost.Radiation oncology (London, England) · 2023Article
- Clinical use of positron emission tomography for radiotherapy planning - Medical physics considerations.Zeitschrift fur medizinische Physik · 2023Review
- Hypoxia in relationship to tumor volume using hypoxia PET-imaging in head & neck cancer - A scoping review.Clinical and translational radiation oncology · 2022Article
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Authors and funding
13 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeTo prospectively assess the prognostic value of tumour hypoxia determined by dynamic [ PATIENTS AND
methodsWe present a planned interim analysis of a randomized phase II trial. N=25 patients with LASCCHN received baseline dynFMISO PET/CT to derive hypoxic volumes (HV). Patients with tumour hypoxia were randomized into standard radiochemotherapy (stdRT) (70Gy/35 fractions) or DE (77Gy/35 fractions) to the HV. Patients with non-hypoxic tumours were treated with stdRT. Loco-regional control (LRC) in hypoxic patients randomized to stdRT was compared to non-hypoxic patients. Feasibility and toxicity were analysed for patients in the DE arm and compared to stdRT.
resultsWith a mean follow-up of 27months, LRC in hypoxic patients receiving stdRT (n=10) was significantly worse compared to the non-hypoxic group (n=5) (2y-LRC 44.4% versus 100%, p=0.048). The respective LRC for the DE group (n=10) was 70.0%. Treatment compliance as well as acute and late toxicity did not show significant differences between the DE and the standard dose arms.
conclusionTumour hypoxia determined by baseline dynFMISO PET/CT is associated with a high risk of local failure in patients with LASCCHN. First data suggest that DE to HV is feasible without excess toxicity.
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