ArticleBioorganic & medicinal chemistry letters2017
Computer-aided discovery of two novel chalcone-like compounds active and selective against Leishmania infantum.
Article in Bioorganic & medicinal chemistry letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
10 citing papers in PubMed, 28 citations in OpenAlex.
- Novel Chalcone Derivatives as Anti-Antibiotics (Basel, Switzerland) · 2025Article
- Flavonoid Derivatives as New Potent Inhibitors of Cysteine Proteases: An Important Step toward the Design of New Compounds for the Treatment of Leishmaniasis.Microorganisms · 2023Article
- The green chemistry of chalcones: Valuable sources of privileged core structures for drug discovery.Frontiers in chemistry · 2022Review
- Curated Data In - TrustworthyAlternatives to laboratory animals : ATLA · 2021Review
- QSAR-Based Virtual Screening of Natural Products Database for Identification of Potent Antimalarial Hits.Biomolecules · 2021Article
- Identification of Chalcone Derivatives as Inhibitors ofFrontiers in chemistry · 2020Article
- Chalcones as a basis for computer-aided drug design: innovative approaches to tackle malaria.Future medicinal chemistry · 2019Article
- Article
- Reverse Screening Methods to Search for the Protein Targets of Chemopreventive Compounds.Frontiers in chemistry · 2018Review
- Chalcone Derivatives: Promising Starting Points for Drug Design.Molecules (Basel, Switzerland) · 2017Review
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 3 countries.
Funding
Abstract
Leishmaniasis are infectious diseases caused by parasites of genus Leishmania that affect affects 12 million people in 98 countries mainly in Africa, Asia, and Latin America. Effective treatments for this disease are urgently needed. In this study, we present a computer-aided approach to investigate a set of 32 recently synthesized chalcone and chalcone-like compounds to act as antileishmanial agents. As a result, nine most promising compounds and three potentially inactive compounds were experimentally evaluated against Leishmania infantum amastigotes and mammalian cells. Four compounds exhibited EC
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.