ArticleBiological psychiatry2017
Compulsive Addiction-like Aggressive Behavior in Mice.
Article in Biological psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 1 of them a synthesis that pooled it.
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Who cites it
61 citing papers in PubMed, 1 synthesis or guideline pooled it, 94 citations in OpenAlex.
- Coordination of social behaviors by the bed nucleus of the stria terminalis.The European journal of neuroscience · 2022Pooled it
- Alcohol abstinence precipitates alcohol seeking and aversion-resistant intake in association with increased BNST activity.Molecular psychiatry · 2026Article
- Attack Repertoires in Outbred Male CD1-Mice Are Associated with Nucleus Accumbens Neuroligin-2.eNeuro · 2026Article
- Lateral hypothalamus to dorsal raphe nucleus projections modulate intraspecific attack behavior in male mice.iScience · 2026Article
- An automated two-choice social operant task for probing moment-to-moment changes in social satiety.iScience · 2025Article
- Addictive-like behavioural traits in pet dogs with extreme motivation for toy play.Scientific reports · 2025Article
- Operant social self-administration in male CD1 mice.Psychopharmacology · 2025Article
- Editorial: Spanning the spectrum of social behavior: towards more translationally relevant animal models.Psychopharmacology · 2025Article
- A review of the effects of different types of social behaviors on the recruitment of neuropeptides and neurotransmitters in the nucleus accumbens.Frontiers in neuroendocrinology · 2025Review
- Article
- Neural mechanisms underlying strain preference behaviour and plasticity in mice.Scientific reports · 2025Article
- Topography of violent intraspecific aggression in a subset of dogs from directionally selected lines of Canis familiaris.PloS one · 2025Article
- Individual Differences in Volitional Social Self-Administration and Motivation in Male and Female Mice Following Social Stress.Biological psychiatry · 2024Article
- Generation and Characterization of a NovelThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Sexually dimorphic oxytocin circuits drive intragroup social conflict and aggression in wild house mice.Nature neuroscience · 2024Article
- Independent inhibitory control mechanisms for aggressive motivation and action.Nature neuroscience · 2024Article
- TheFrontiers in psychology · 2024Article
- A critical role for cortical amygdala circuitry in shaping social encounters.Research square · 2023Article
- An operant social self-administration and choice model in mice.Nature protocols · 2023Review
- How social information impacts action in rodents and humans: the role of the prefrontal cortex and its connections.Neuroscience and biobehavioral reviews · 2023Review
1 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundSome people are highly motivated to seek aggressive encounters, and among those who have been incarcerated for such behavior, recidivism rates are high. These observations echo two core features of drug addiction: high motivation to seek addictive substances, despite adverse consequences, and high relapse rates. Here we used established rodent models of drug addiction to determine whether they would be sensitive to "addiction-like" features of aggression in CD-1 mice.
methodsIn experiments 1 and 2, we trained older CD-1 mice to lever press for opportunities to attack younger C57BL6/J mice. We then tested them for relapse to aggression seeking after forced abstinence or punishment-induced suppression of aggression self-administration. In experiment 3, we trained a large cohort of CD-1 mice and tested them for choice-based voluntary suppression of aggression seeking, relapse to aggression seeking, progressive ratio responding, and punishment-induced suppression of aggression self-administration. We then used cluster analysis to identify patterns of individual differences in compulsive "addiction-like" aggressive behavior.
resultsIn experiments 1 and 2, we observed strong motivation to acquire operant self-administration of opportunities to aggress and relapse vulnerability during abstinence. In experiment 3, cluster analysis of the aggression-related measures identified a subset of "addicted" mice (∼19%) that exhibited intense operant-reinforced attack behavior, decreased likelihood to select an alternative reinforcer over aggression, heightened relapse vulnerability and progressive ratio responding, and resilience to punishment-induced suppression of aggressive behavior.
conclusionsUsing procedures established to model drug addiction, we showed that a subpopulation of CD-1 mice demonstrate "addiction-like" aggressive behavior, suggesting an evolutionary origin for compulsive aggression.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.