Evidence map›Paper›PMID 28434403›Full record

ReviewJournal of hematology & oncology2017

Immunotherapy in genitourinary malignancies.

Kathan Mehta, Keyur Patel, Rahul A Parikh

Open access · goldAbstract readReview
In one paragraph

Review in Journal of hematology & oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 39 citations in OpenAlex.

  1. Review
  2. Article
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  5. Review
  6. Article
  7. Article
  8. Article
  9. Latest progress in molecular biology and treatment in genitourinary tumours.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2020
    Review
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  14. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Kathan MehtaDepartment of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Keyur PatelDepartment of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Rahul A ParikhDepartment of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA. parikhr@upmc.edu.
University of Pittsburgh Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Treatment of cancer patients involves a multidisciplinary approach including surgery, radiotherapy, and chemotherapy. Traditionally, patients with metastatic disease are treated with combination chemotherapies or targeted agents. These cytotoxic agents have good response rates and achieve palliation; however, complete responses are rarely seen. The field of cancer immunology has made rapid advances in the past 20 years. Recently, a number of agents and vaccines, which modulate the immune system to allow it to detect and target cancer cells, are being developed. The benefit of these agents is twofold, it enhances the ability the body's own immune system to fight cancer, thus has a lower incidence of side effects compared to conventional cytotoxic chemotherapy. Secondly, a small but substantial number of patients with metastatic disease are cured by immunotherapy or achieve durable responses lasting for a number of years. In this article, we review the FDA-approved immunotherapy agents in the field of genitourinary malignancies. We also summarize new immunotherapy agents being evaluated in clinical studies either as single agents or as a combination.

Indexed as

ImmunotherapyAdaptive ImmunityAntibodies, MonoclonalAntineoplastic Agents, ImmunologicalB7-H1 AntigenBiomarkersCancer VaccinesClinical Trials as TopicCTLA-4 AntigenHumansImmunity, InnateInterferon-alphaInterleukin-2Multicenter Studies as TopicNeoplasm ProteinsProgrammed Cell Death 1 ReceptorAntibodies, MonoclonalAntineoplastic Agents, ImmunologicalB7-H1 AntigenBiomarkersCancer VaccinesCD274 protein, humanCTLA-4 AntigenInterferon-alphaInterleukin-2Neoplasm ProteinsPDCD1 protein, humanProgrammed Cell Death 1 ReceptorPROSTVACAtezolizumabBCGBladderCancerCheckpoint inhibitorCTLA-4DurvalumabGenitourinary malignancyImmunotherapyInterleukinIpilimumabKidneyNivolumabPD-1PD-L1PembrolizumabProstatePROSTVACSipuleucel-T

Identifiers

PMID28434403
PMCPMC5402074
OpenAlexW2605490210

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.