Evidence map›Paper›PMID 28434161›Full record

ArticleNeurochemical research2017

Can Valproic Acid Regulate Neurogenesis from Nestin+ Cells in the Adult Midbrain?

Parisa Farzanehfar, Malcolm K Horne, Tim D Aumann

Abstract read
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In one paragraph

Article in Neurochemical research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Parisa FarzanehfarFlorey Institute for Neuroscience & Mental Health, The University of Melbourne, Parkville, VIC, 3010, Australia. parisa.farzanehfar@florey.edu.au.ORCID http://orcid.org/0000-0002-6221-4077
Malcolm K HorneFlorey Institute for Neuroscience & Mental Health, The University of Melbourne, Parkville, VIC, 3010, Australia.
Tim D AumannFlorey Institute for Neuroscience & Mental Health, The University of Melbourne, Parkville, VIC, 3010, Australia.
The University of Melbourne · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Degeneration of dopamine (DA) neurons in the substantia nigra pars compacta (SNc) causes the motor symptoms (e.g. tremor, muscle rigidity, bradykinesia, postural instability) of Parkinson's disease (PD). It is generally agreed that replacing these neurons will provide better motor symptom relief and fewer side effects than current pharmacotherapies. One potential approach to this is up-regulating endogenous DA neurogenesis in SNc. In the present study, we conducted bioinformatics analyses to identify signalling pathways that control expression of Pax6 and Msx1 genes, which have been identified as potentially important neurogenic regulators in the adult midbrain. From this Valproic acid (VPA) was identified as a regulator of these pathways, and we tested VPA for its ability to regulate midbrain neurogenesis in adult mice. VPA was infused directly into the midbrain of adult NesCreER

Indexed as

Age FactorsAnimalsInfusion Pumps, ImplantableMesencephalonMiceMice, Inbred C57BLMice, TransgenicNestinNeural Stem CellsNeurogenesisRandom AllocationValproic AcidNestinValproic AcidAdult neurogenesisDopamineParkinson’s diseaseSubstantia nigraValproic acid

Identifiers

PMID28434161
OpenAlexW2606420144

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.