Evidence map›Paper›PMID 28434122›Full record

SynthesisRheumatology international2017

The status of pulmonary fibrosis in systemic sclerosis is associated with IRF5, STAT4, IRAK1, and CTGF polymorphisms.

Wenjie Zhao, Xiaoyang Yue, Kuai Liu, Junfeng Zheng, Runda Huang, Jun Zou, Gabriela Riemekasten, Frank Petersen, Xinhua Yu

Abstract readMeta-AnalysisReview
PubMed Publisher
In one paragraph

Synthesis in Rheumatology international, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Variants inInternational journal of molecular sciences · 2026
    Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. The Immunogenetics of Systemic Sclerosis.Advances in experimental medicine and biology · 2022
    Article
  10. Article
  11. Review
  12. Review
  13. Pathogenesis of systemic sclerosis associated interstitial lung disease.Journal of scleroderma and related disorders · 2020
    Article
  14. Article
  15. Cryptotanshinone Ameliorates Radiation-Induced Lung Injury in Rats.Evidence-based complementary and alternative medicine : eCAM · 2019
    Article
  16. Review
  17. Major lung complications of systemic sclerosis.Nature reviews. Rheumatology · 2018
    Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Wenjie ZhaoXiamen-Borstel Joint Laboratory of Autoimmunity, Medical College of Xiamen University, Xiang'an Nan Rd., Xiamen, 361102, China.
Xiaoyang YuePriority Area Asthma and Allergy, Research Center Borstel, Airway Research Center North (ARCN), German Center for Lung Research (DZL), Parkallee 22, 23845, Borstel, Germany.
Kuai LiuXiamen-Borstel Joint Laboratory of Autoimmunity, Medical College of Xiamen University, Xiang'an Nan Rd., Xiamen, 361102, China.
Junfeng ZhengXiamen-Borstel Joint Laboratory of Autoimmunity, Medical College of Xiamen University, Xiang'an Nan Rd., Xiamen, 361102, China.
Runda HuangXiamen-Borstel Joint Laboratory of Autoimmunity, Medical College of Xiamen University, Xiang'an Nan Rd., Xiamen, 361102, China.
Jun ZouXiamen-Borstel Joint Laboratory of Autoimmunity, Medical College of Xiamen University, Xiang'an Nan Rd., Xiamen, 361102, China.
Gabriela RiemekastenPriority Area Asthma and Allergy, Research Center Borstel, Airway Research Center North (ARCN), German Center for Lung Research (DZL), Parkallee 22, 23845, Borstel, Germany.
Frank PetersenPriority Area Asthma and Allergy, Research Center Borstel, Airway Research Center North (ARCN), German Center for Lung Research (DZL), Parkallee 22, 23845, Borstel, Germany.
Xinhua YuXiamen-Borstel Joint Laboratory of Autoimmunity, Medical College of Xiamen University, Xiang'an Nan Rd., Xiamen, 361102, China. xinhuayu@fz-borstel.de.
Xiamen University · CNGerman Center for Lung Research · DEUniversity of Lübeck · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pulmonary fibrosis (PF) is one of the leading causes of death in systemic sclerosis (SSc) patients. Although all SSc patients are characterized by autoimmunity, only part of them suffer from PF, suggesting that beside autoimmunity, some additional factors are involved in the initiation of PF in SSc. In this study, we aimed to identify genetic polymorphisms associated with the status of PF in SSc. We performed that an exhaustive search of the PubMed database was performed to identify eligible studies. Then, a comprehensive meta-analysis was performed by comparing PF

Indexed as

Case-Control StudiesConnective Tissue Growth FactorGenetic MarkersGenetic Predisposition to DiseaseGenotypeHumansInterferon Regulatory FactorsInterleukin-1 Receptor-Associated KinasesPolymorphism, Single NucleotidePulmonary FibrosisScleroderma, SystemicSTAT4 Transcription FactorCCN2 protein, humanConnective Tissue Growth FactorGenetic MarkersInterferon Regulatory FactorsInterleukin-1 Receptor-Associated KinasesIRAK1 protein, humanIRF5 protein, humanSTAT4 protein, humanSTAT4 Transcription FactorExtracellular matrixGeneticsInnate immunityPulmonary fibrosisSystemic sclerosis

Identifiers

PMID28434122
OpenAlexW2605580724

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.