ArticleJournal of autism and developmental disorders2017
Medical Conditions in the First Years of Life Associated with Future Diagnosis of ASD in Children.
Article in Journal of autism and developmental disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Examining the association between autism spectrum disorder and atopic eczema: meta-analysis of current evidence.Pediatric research · 2025Pooled it
- Risk factors for inflammatory bowel disease: an umbrella review.Frontiers in cellular and infection microbiology · 2024Pooled it
- Population-Based Psychiatric Comorbidity in Children and Adolescents With Autism Spectrum Disorder: A Meta-Analysis.Frontiers in psychiatry · 2022Pooled it
- Association between Copy Number Variation and Response to Social Skills Training in Autism Spectrum Disorder.Scientific reports · 2019Trial
- A Cross-Neurotype Analysis of Camouflaging and Illness Perceptions in People with Central Sensitivity Syndromes.Autism in adulthood · 2026Article
- Evaluation of causal relationships between genetic liability to inflammatory bowel disease and autism spectrum disorder by Mendelian randomization analysis.Dialogues in clinical neuroscience · 2025Article
- Changes in Autism Traits from Early Childhood To Adolescence in the Study To Explore Early Development.Journal of autism and developmental disorders · 2025Article
- Borrowing From the Future: Enhancing Early Risk Assessment through Contrastive Learning.Proceedings of machine learning research · 2025Article
- Changes in Autism Traits from Early Childhood to Adolescence in the Study to Explore Early Development.medRxiv : the preprint server for health sciences · 2025Article
- Predicting neurodevelopmental disorders using machine learning models and electronic health records - status of the field.Journal of neurodevelopmental disorders · 2024Review
- Estimating the Prevalence of Autism Spectrum Disorder in New South Wales, Australia: A Data Linkage Study of Three Routinely Collected Datasets.Journal of autism and developmental disorders · 2024Article
- A Developmental Social Neuroscience Perspective on Infant Autism Interventions.Annual review of developmental psychology · 2023Article
- Brief Report: The Characterization of Medical Comorbidity Prior to Autism Diagnosis in Children Before Age Two.Journal of autism and developmental disorders · 2023Article
- Observational
- Prediction of autism in infants: progress and challenges.The Lancet. Neurology · 2023Review
- Link between the skin and autism spectrum disorder.Frontiers in psychiatry · 2023Article
- Association of maternal autoimmune disease and early childhood infections with offspring autism spectrum disorder: A population-based cohort study.Autism research : official journal of the International Society for Autism Research · 2022Article
- Bringing machine learning to research on intellectual and developmental disabilities: taking inspiration from neurological diseases.Journal of neurodevelopmental disorders · 2022Review
- Assessing Interdisciplinary Trainees' Objective and Self-Reported Knowledge of Autism Spectrum Disorder and Confidence in Providing Services.Journal of autism and developmental disorders · 2022Article
- Assessing the validity of administrative health data for the identification of children and youth with autism spectrum disorder in Ontario.Autism research : official journal of the International Society for Autism Research · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
This study examines medical conditions diagnosed prior to the diagnosis of autism spectrum disorder (ASD). Using a matched case control design with 3911 ASD cases and 38,609 controls, we found that 38 out of 79 medical conditions were associated with increased ASD risk. Developmental delay, mental health, and neurology conditions had the strongest associations (ORs 2.0-23.3). Moderately strong associations were observed for nutrition, genetic, ear nose and throat, and sleep conditions (ORs 2.1-3.2). Using machine learning methods, we clustered children based on their medical conditions prior to ASD diagnosis and demonstrated ASD risk stratification. Our findings provide new evidence indicating that children with ASD have a disproportionate burden of certain medical conditions preceding ASD diagnosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.