Evidence map›Paper›PMID 28434038›Full record

ReviewCellular and molecular life sciences : CMLS2017

Emerging potential of gene silencing approaches targeting anti-chondrogenic factors for cell-based cartilage repair.

Andrea Lolli, Letizia Penolazzi, Roberto Narcisi, Gerjo J V M van Osch, Roberta Piva

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cellular and molecular life sciences : CMLS, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Intra-articular drug delivery systems for joint diseases.Current opinion in pharmacology · 2018
    Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Andrea LolliDepartment of Orthopaedics, Erasmus MC, University Medical Center, 3015 CN, Rotterdam, The Netherlands. a.lolli@erasmusmc.nl.
Letizia PenolazziDepartment of Biomedical and Specialty Surgical Sciences, University of Ferrara, Ferrara, Italy.
Roberto NarcisiDepartment of Orthopaedics, Erasmus MC, University Medical Center, 3015 CN, Rotterdam, The Netherlands.
Gerjo J V M van OschDepartment of Orthopaedics, Erasmus MC, University Medical Center, 3015 CN, Rotterdam, The Netherlands.
Roberta PivaDepartment of Biomedical and Specialty Surgical Sciences, University of Ferrara, Ferrara, Italy. piv@unife.it.

Funding

European Union's Horizon 2020 research and innovation programme, Marie Sklodowska Curie No 642414VENI grant by STW 13659
6 · The paper itself

Abstract

The field of cartilage repair has exponentially been growing over the past decade. Here, we discuss the possibility to achieve satisfactory regeneration of articular cartilage by means of human mesenchymal stem cells (hMSCs) depleted of anti-chondrogenic factors and implanted in the site of injury. Different types of molecules including transcription factors, transcriptional co-regulators, secreted proteins, and microRNAs have recently been identified as negative modulators of chondroprogenitor differentiation and chondrocyte function. We review the current knowledge about these molecules as potential targets for gene knockdown strategies using RNA interference (RNAi) tools that allow the specific suppression of gene function. The critical issues regarding the optimization of the gene silencing approach as well as the delivery strategies are discussed. We anticipate that further development of these techniques will lead to the generation of implantable hMSCs with enhanced potential to regenerate articular cartilage damaged by injury, disease, or aging.

Indexed as

ChondrogenesisMesenchymal Stem Cell TransplantationRegenerationRNA InterferenceAnimalsCartilage, ArticularHumansMesenchymal Stem CellsRNAi TherapeuticsRNA, Small InterferingRNA, UntranslatedTranscription FactorsRNA, Small InterferingRNA, UntranslatedTranscription FactorsAnti-chondrogenic regulatorsCartilage repairChondrogenesisGene silencingMesenchymal stem cellsMicroRNARNA interference

Identifiers

PMID28434038
PMCPMC11107620

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.