Evidence map›Paper›PMID 28434027›Full record

ArticlePediatric radiology2017

Can ultrasound be used as the primary imaging in children with suspected Crohn disease?

Timothy L Tsai, Megan B Marine, Matthew R Wanner, Matthew L Cooper, Steven J Steiner, Fangqian Ouyang, S Gregory Jennings, Boaz Karmazyn

Abstract read
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In one paragraph

Article in Pediatric radiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Timothy L TsaiDepartment of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA.
Megan B MarineDepartment of Radiology and Imaging Sciences, Riley Hospital for Children, 702 Barnhill Drive, Room 1053, Indianapolis, IN, 46202, USA.
Matthew R WannerDepartment of Radiology and Imaging Sciences, Riley Hospital for Children, 702 Barnhill Drive, Room 1053, Indianapolis, IN, 46202, USA.
Matthew L CooperDepartment of Radiology and Imaging Sciences, Riley Hospital for Children, 702 Barnhill Drive, Room 1053, Indianapolis, IN, 46202, USA.
Steven J SteinerDepartment of Gastroenterology, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN, USA.
Fangqian OuyangDepartment of Biostatistics, Indiana University School of Medicine, Indianapolis, IN, USA.
S Gregory JenningsDepartment of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA.
Boaz KarmazynDepartment of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA. bkarmazy@iupui.edu.
Riley Hospital for Children · USIndiana University School of MedicineIndiana University – Purdue University Indianapolis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere is growing literature on the use of ultrasound (US) for evaluation of Crohn disease in adults, but few studies have been conducted on children. Several studies demonstrated high accuracy of US in the diagnosis of Crohn disease. Using US as the primary screening imaging modality for Crohn disease can reduce health care costs, the need for sedation and ionizing radiation exposure.

objectiveThe aim of our study is to determine if US can be used for screening evaluation of pediatric Crohn disease. MATERIALS AND

methodsA prospective cohort study of pediatric patients undergoing MR enterography (MRE) for suspected or known history of Crohn disease was performed, with gray-scale and Doppler US of the terminal ileum done immediately before or after MRE. US images were interpreted by two radiologists (Reader 1 and Reader 2) not involved in image acquisition, in blinded and randomized fashion. US findings of Crohn disease including bowel wall thickening, wall stratification, increased vascularity on Doppler, lymphadenopathy, fat infiltration and extraintestinal complications were evaluated. MRE findings of terminal ileitis were considered the reference standard. Demographic data, body mass index (BMI), symptoms, and laboratory, endoscopic and histopathological data were obtained from electronic medical records.

resultsForty-one patients (mean age: 13.7 years: 4.6-18.9 years) were evaluated. Mean BMI was 21.2 (range: 13-40.2); 10 patients (24.3%) were either overweight or obese. Final diagnoses were Crohn disease (n=24), ulcerative colitis (n=4) and normal/non-inflammatory bowel disease-related diagnoses (n=13). US demonstrated sensitivity of 67% and 78% and specificity of 78% and 83%, by Reader 1 and Reader 2, respectively. MRE sensitivity and specificity were 75% and 100%, respectively, compared to final clinicopathological diagnosis. Interobserver agreement between Reader 1 and Reader 2 was good (0.6< kappa <0.8).

conclusionIn screening for Crohn disease in children, US has limited sensitivity for detecting terminal ileitis.

Indexed as

AdolescentChildChild, PreschoolCrohn DiseaseFemaleHumansMaleProspective StudiesSensitivity and SpecificityUltrasonographyChildrenCrohn diseaseInflammatory bowel diseaseMagnetic resonance enterographyUltrasound

Identifiers

PMID28434027
OpenAlexW2605799684

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.