ArticleEuropean journal of clinical pharmacology2017
Correlation between proton pump inhibitors and risk of pyogenic liver abscess.
Article in European journal of clinical pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 56 citations in OpenAlex.
- Incidence, Risk Factors, and Subsequent Health Outcomes of Pyogenic Liver Abscesses: A Scoping Review of Evidence From Population-Based Studies.Gastroenterology research and practice · 2025Review
- Clinical characteristics, pathogenic bacteria, and risk factors for different locations of pyogenic liver abscesses: a 10-year analysis.Frontiers in cellular and infection microbiology · 2025Article
- Article
- Proton Pump Inhibitor Use Increases Pyogenic Liver Abscess Risk: A Nationwide Cohort Study.Journal of neurogastroenterology and motility · 2021Article
- Risk of Pyogenic Liver Abscess in Proton Pump Inhibitor Users: New Inventory of Proton Pump Inhibitor Induced Complications?Journal of neurogastroenterology and motility · 2021Article
- Epidemiology and risk factors for pyogenic liver abscess in the Calgary Health Zone revisited: a population-based study.BMC infectious diseases · 2021Article
- Article
- When hiccups mean something more than just a nuisance: A rare presentation of pyogenic liver abscess.JGH open : an open access journal of gastroenterology and hepatology · 2021Article
- Is the Use of Proton Pump Inhibitors a Predisposing Factor for Pyogenic Liver Abscesses?Gastroenterology research · 2021Article
- Rapidly developing, large pyogenic liver abscesses in the setting of pancreatic cancer.Proceedings (Baylor University. Medical Center) · 2021Article
- Maximal diameter of liver abscess independently predicts prolonged hospitalization and poor prognosis in patients with pyogenic liver abscess.BMC infectious diseases · 2021Article
- Epidemiological, Clinical, Microbiological, and Risk Factors of Pyogenic Liver Abscess: An 18-years Retrospective Single-Center Analysis.Journal of community hospital internal medicine perspectives · 2021Article
- Article
- Analysis of the clinical characteristics of 202 patients with liver abscess associated with diabetes mellitus and biliary tract disease.The Journal of international medical research · 2020Article
- Pyogenic liver abscesses concomitant with advanced gastric cancer: a case report.Clinical journal of gastroenterology · 2020Article
- Association of hepatocellular carcinoma with thiazolidinediones use: A population-based case-control study.Medicine · 2020Observational
- Association between Parkinson's disease and proton pump inhibitors therapy in older people.BioMedicine · 2020Article
- Article
- Association between colorectal cancer and thiazolidinediones administration in a case-control study.BioMedicine · 2019Article
- Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectiveLittle is known about the relationship between proton pump inhibitors use and pyogenic liver abscess. The objective of this study was to evaluate the correlation between proton pump inhibitors use and pyogenic liver abscess in Taiwan.
methodsThis was a population-based case-control study using the database of the Taiwan National Health Insurance Program since 2000 to 2011. Subjects aged 20 to 84 who experienced their first episode of pyogenic liver abscess were enrolled as the case group (n = 1372). Randomly selected subjects aged 20 to 84 without pyogenic liver abscess were enrolled as the control group (n = 1372). Current use, early use, and late use of proton pump inhibitors was defined as subjects whose last one tablet for proton pump inhibitors was noted ≤30 days, between 31 to 90 days and ≥91 days before the date of admission for pyogenic liver abscess. Subjects who never received a prescription for proton pump inhibitors were defined as nonusers of proton pump inhibitors. A multivariable unconditional logistic regression model was used to measure the odds ratio and 95% confidence interval to evaluate the correlation between proton pump inhibitors use and pyogenic liver abscess.
resultsAfter adjusting for confounders, the adjusted odds ratio of pyogenic liver abscess was 7.59 for subjects with current use of proton pump inhibitors (95% confidence interval 5.05, 11.4), when compared with nonusers.
conclusionsCurrent use of proton pump inhibitors is associated with a greater risk of pyogenic liver abscess.
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