Evidence map›Paper›PMID 28434020›Full record

ArticleClinical research in cardiology : official journal of the German Cardiac Society2017

Bisoprolol compared with carvedilol and metoprolol succinate in the treatment of patients with chronic heart failure.

Hanna Fröhlich, Lorella Torres, Tobias Täger, Dieter Schellberg, Anna Corletto, Syed Kazmi, Kevin Goode, Morten Grundtvig, Torstein Hole, Hugo A Katus and 5 more

Open access · greenAbstract readComparative Study
PubMed Publisher
In one paragraph

Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 42 citations in OpenAlex.

  1. Long-term effects of device-guided slow breathing in stable heart failure patients with reduced ejection fraction.Clinical research in cardiology : official journal of the German Cardiac Society · 2019
    Trial
  2. Noninvasive pulse contour analysis for determination of cardiac output in patients with chronic heart failure.Clinical research in cardiology : official journal of the German Cardiac Society · 2018
    Trial
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Comparison between the ECG Outcomes of Metoprolol and Bisoprolol.Cardiovascular & hematological agents in medicinal chemistry · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. βFrontiers in cardiovascular medicine · 2021
    Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Observational
  19. New drugs: big changes in conservative heart failure therapy?European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2019
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 8 institutions in 3 countries.

Hanna FröhlichDepartment of Cardiology, Angiology and Pulmology, University Hospital Heidelberg, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
Lorella TorresDepartment of Cardiology, Angiology and Pulmology, University Hospital Heidelberg, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
Tobias TägerDepartment of Cardiology, Angiology and Pulmology, University Hospital Heidelberg, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
Dieter SchellbergDepartment of Cardiology, Angiology and Pulmology, University Hospital Heidelberg, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
Anna CorlettoDepartment of Cardiology, Angiology and Pulmology, University Hospital Heidelberg, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
Syed KazmiCastle Hill Hospital, Hull York Medical School, Hull, UK.
Kevin GoodeHull York Medical School, University of Hull, Hull, UK.
Morten GrundtvigMedical Department, Innlandet Hospital Trust Division Lillehammer, Lillehammer, Norway.
Torstein HoleMedical Faculty, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
Hugo A KatusDepartment of Cardiology, Angiology and Pulmology, University Hospital Heidelberg, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
John G F ClelandNational Heart and Lung Institute, Royal Brompton, Harefield Hospitals, Imperial College, London, UK.
Dan AtarDepartment of Cardiology, Oslo University Hospital, Ulleval and Institute of Clinical Sciences, University of Oslo, Oslo, Norway.
Andrew L ClarkCastle Hill Hospital, Hull York Medical School, Hull, UK.
Stefan AgewallDepartment of Cardiology, Oslo University Hospital, Ulleval and Institute of Clinical Sciences, University of Oslo, Oslo, Norway.
Lutz FrankensteinDepartment of Cardiology, Angiology and Pulmology, University Hospital Heidelberg, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany. Lutz.Frankenstein@med.uni-heidelberg.de.
Heidelberg University · DEUniversity Hospital Heidelberg · DECastle Hill Hospital · GBUniversity of Oslo · NOHarefield Hospital · GBInnlandet Hospital Trust · NONorwegian University of Science and Technology · NOUniversity of Hull · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsBeta-blockers are recommended for the treatment of chronic heart failure (CHF). However, it is disputed whether beta-blockers exert a class effect or whether there are differences in efficacy between agents. METHODS AND

results6010 out-patients with stable CHF and a reduced left ventricular ejection fraction prescribed either bisoprolol, carvedilol or metoprolol succinate were identified from three registries in Norway, England, and Germany. In three separate matching procedures, patients were individually matched with respect to both dose equivalents and the respective propensity scores for beta-blocker treatment. During a follow-up of 26,963 patient-years, 302 (29.5%), 637 (37.0%), and 1232 (37.7%) patients died amongst those prescribed bisoprolol, carvedilol, and metoprolol, respectively. In univariable analysis of the general sample, bisoprolol and carvedilol were both associated with lower mortality as compared with metoprolol succinate (HR 0.80, 95% CI 0.71-0.91, p < 0.01, and HR 0.86, 95% CI 0.78-0.94, p < 0.01, respectively). Patients prescribed bisoprolol or carvedilol had similar mortality (HR 0.94, 95% CI 0.82-1.08, p = 0.37). However, there was no significant association between beta-blocker choice and all-cause mortality in any of the matched samples (HR 0.90; 95% CI 0.76-1.06; p = 0.20; HR 1.10, 95% CI 0.93-1.31, p = 0.24; and HR 1.08, 95% CI 0.95-1.22, p = 0.26 for bisoprolol vs. carvedilol, bisoprolol vs. metoprolol succinate, and carvedilol vs. metoprolol succinate, respectively). Results were confirmed in a number of important subgroups.

conclusionOur results suggest that the three beta-blockers investigated have similar effects on mortality amongst patients with CHF.

Indexed as

Adrenergic beta-1 Receptor AntagonistsAgedAged, 80 and overBisoprololCarbazolesCarvedilolChronic DiseaseEnglandFemaleFollow-Up StudiesGermanyHeart FailureHumansMaleMetoprololMiddle AgedAdrenergic beta-1 Receptor AntagonistsBisoprololCarbazolesCarvedilolMetoprololPropanolaminesBeta-blockerEffectivenessHeart failure with reduced ejection fractionSurvival

Identifiers

PMID28434020
OpenAlexW2607376927

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.