Evidence map›Paper›PMID 28433734›Full record

ArticleAmerican journal of obstetrics and gynecology2017

Prospective association of fetal liver blood flow at 30 weeks gestation with newborn adiposity.

Satoru Ikenoue, Feizal Waffarn, Masanao Ohashi, Kaeko Sumiyoshi, Chigusa Ikenoue, Claudia Buss, Daniel L Gillen, Hyagriv N Simhan, Sonja Entringer, Pathik D Wadhwa

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PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of obstetrics and gynecology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Observational
  3. Origins of obesity in the womb: Fetal adiposity and its determinants.The journal of obstetrics and gynaecology research · 2024
    Review
  4. Review
  5. Placental Corticotrophin-Releasing Hormone is a Modulator of Fetal Liver Blood Perfusion.The Journal of clinical endocrinology and metabolism · 2021
    Article
  6. Observational
  7. Review
  8. Observational
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Satoru IkenoueDepartment of Pediatrics, University of California, Irvine, Irvine, CA; Development, Health and Disease Research Program, University of California, Irvine, Irvine, CA; Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.
Feizal WaffarnDepartment of Pediatrics, University of California, Irvine, Irvine, CA; Development, Health and Disease Research Program, University of California, Irvine, Irvine, CA.
Masanao OhashiDepartment of Pediatrics, University of California, Irvine, Irvine, CA; Development, Health and Disease Research Program, University of California, Irvine, Irvine, CA; Department of Obstetrics and Gynecology, University of Miyazaki, Miyazaki, Japan.
Kaeko SumiyoshiDepartment of Pediatrics, University of California, Irvine, Irvine, CA; Development, Health and Disease Research Program, University of California, Irvine, Irvine, CA; Department of Obstetrics and Gynecology, University of Miyazaki, Miyazaki, Japan.
Chigusa IkenoueDepartment of Pediatrics, University of California, Irvine, Irvine, CA; Development, Health and Disease Research Program, University of California, Irvine, Irvine, CA.
Claudia BussDepartment of Pediatrics, University of California, Irvine, Irvine, CA; Development, Health and Disease Research Program, University of California, Irvine, Irvine, CA; Institute of Medical Psychology, Charité University Medicine, Berlin, Germany.
Daniel L GillenDepartment of Statistics, University of California, Irvine, Irvine, CA; Development, Health and Disease Research Program, University of California, Irvine, Irvine, CA.
Hyagriv N SimhanDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, PA.
Sonja EntringerDepartment of Pediatrics, University of California, Irvine, Irvine, CA; Development, Health and Disease Research Program, University of California, Irvine, Irvine, CA; Institute of Medical Psychology, Charité University Medicine, Berlin, Germany.
Pathik D WadhwaDepartment of Pediatrics, University of California, Irvine, Irvine, CA; Department of Psychiatry and Human Behavior, University of California, Irvine, Irvine, CA; Department of Obstetrics and Gynecology, University of California, Irvine, Irvine, CA; Department of Epidemiology, University of California, Irvine, Irvine, CA; Development, Health and Disease Research Program, University of California, Irvine, Irvine, CA. Electronic address: pwadhwa@uci.edu.
University of California, Irvine · USUniversity of Miyazaki · JPUniversity of Pittsburgh · US

Funding

University of California Health Participation in the National COVID Cohort Collaborative (N3C)UL1TR001414 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M, VILAIN, ERIC J. · 2015 to 2023
$35.1M
Maternal Acculturation in Pregnancy and Infant Adiposity in Mexican AmericansR01MD010738 · NIMHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI ENTRINGER, SONJA, WADHWA, PATHIK D · 2016 to 2020
$3.6M
EMA Assessment of Biobehavioral Processes in Human PregnancyR01HD060628 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI WADHWA, PATHIK D · 2010 to 2014
$3.4M
FETAL PROGRAMMING OF THE NEWBORN AND INFANT HUMAN BRAINR01MH091351 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI BUSS, CLAUDIA, WADHWA, PATHIK D · 2011 to 2015
$3.3M
Prenatal stress biology, infant body composition and obesity riskR01HD065825 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI ENTRINGER, SONJA, WADHWA, PATHIK D · 2010 to 2014
$2.2M
NCATS NIH HHS UL1 TR001414NICHD NIH HHS R01 HD060628NICHD NIH HHS R01 HD065825NIMHD NIH HHS R01 MD010738NIMH NIH HHS R01 MH091351
6 · The paper itself

Abstract

backgroundThe production of variation in adipose tissue accretion represents a key fetal adaptation to energy substrate availability during gestation. Because umbilical venous blood transports nutrient substrate from the maternal to the fetal compartment and because the fetal liver is the primary organ in which nutrient interconversion occurs, it has been proposed that variations in the relative distribution of umbilical venous blood flow shunting either through ductus venosus or perfusing the fetal liver represents a mechanism underlying this adaptation.

objectiveThe objective of the present study was to determine whether fetal liver blood flow assessed before the period of maximal fetal fat deposition (ie, the third trimester of gestation) is prospectively associated with newborn adiposity. STUDY

designA prospective study was conducted in a cohort of 62 uncomplicated singleton pregnancies. Fetal ultrasonography was performed at 30 weeks gestation for conventional fetal biometry and characterization of fetal liver blood flow (quantified by subtracting ductus venosus flow from umbilical vein flow). Newborn body fat percentage was quantified by dual energy X-ray absorptiometry imaging at 25.8 ± 3.3 (mean ± standard error of the mean) postnatal days. Multiple regression analysis was used to determine the proportion of variation in newborn body fat percentage explained by fetal liver blood flow. Potential confounding factors included maternal age, parity, prepregnancy body mass index, gestational weight gain, gestational age at birth, infant sex, postnatal age at dual energy X-ray absorptiometry scan, and mode of infant feeding.

resultsNewborn body fat percentage was 13.5% ± 2.4% (mean ± standard error of the mean). Fetal liver blood flow at 30 weeks gestation was significantly and positively associated with newborn total fat mass (r=0.397; P<.001) and body fat percentage (r=0.369; P=.004), but not with lean mass (r=0.100; P=.441). After accounting for the effects of covariates, fetal liver blood flow explained 13.5% of the variance in newborn fat mass. The magnitude of this association was pronounced particularly in nonoverweight/nonobese mothers (prepregnancy body mass index, <25 kg/m

conclusionFetal liver blood flow at the beginning of the third trimester of gestation is associated positively with newborn adiposity, particularly among nonoverweight/nonobese mothers. This finding supports the role of fetal liver blood flow as a putative fetal adaptation underlying variation in adipose tissue accretion.

Indexed as

AdiposityBody Mass IndexFemaleGestational AgeHumansInfant, NewbornLiverMalePregnancyProspective StudiesRegional Blood Flowbody compositionbody fat percentagefetal ultrasonographyliver blood flowprepregnancy body mass index

Identifiers

PMID28433734
PMCPMC5545060
OpenAlexW2564505922

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.