Evidence map›Paper›PMID 28433661›Full record

ArticleFree radical biology & medicine2017

Differential protein acetylation assists import of excess SOD2 into mitochondria and mediates SOD2 aggregation associated with cardiac hypertrophy in the murine SOD2-tg heart.

Liwen Zhang, Chwen-Lih Chen, Patrick T Kang, Zhicheng Jin, Yeong-Renn Chen

Open access · greenAbstract read
In one paragraph

Article in Free radical biology & medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Mitochondrial redox regulation and myocardial ischemia-reperfusion injury.American journal of physiology. Cell physiology · 2022
    Review
  10. Article
  11. Article
  12. Article
  13. Reductive stress in striated muscle cells.Cellular and molecular life sciences : CMLS · 2020
    Review
  14. Article
  15. SOD2 acetylation and deacetylation: Another tale of Jekyll and Hyde in cancer.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  16. Article
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Liwen ZhangCampus Chemical Instrument Center, Proteomics and Mass Spectrometry Facility, The Ohio State University, Columbus, OH 43210, USA.
Chwen-Lih ChenDepartment of Integrative Medical Sciences, College of Medicine, Northeast Ohio Medical University, Rootstown, OH 44272, USA.
Patrick T KangDepartment of Integrative Medical Sciences, College of Medicine, Northeast Ohio Medical University, Rootstown, OH 44272, USA.
Zhicheng JinDepartment of Pharmaceutical Sciences, College of Medicine, Northeast Ohio Medical University, Rootstown, OH 44272, USA.
Yeong-Renn ChenDepartment of Integrative Medical Sciences, College of Medicine, Northeast Ohio Medical University, Rootstown, OH 44272, USA. Electronic address: ychen1@neomed.edu.
Northeast Ohio Medical University · USThe Ohio State University · US

Funding

Myocardial Injury Mitochondria/ Oxygen Free Radical(s)R01HL083237 · NHLBI · OHIO STATE UNIVERSITY · PI CHEN, YEONG-RENN · 2006 to 2017
$3.8M
NHLBI NIH HHS R01 HL083237
6 · The paper itself

Abstract

SOD2 is the primary antioxidant enzyme neutralizing

Indexed as

AcetylationAnimalsCardiomegalyCytosolHeartMiceMice, TransgenicMitochondriaProtein Aggregation, PathologicalProtein FoldingProtein Processing, Post-TranslationalProtein TransportReactive Oxygen SpeciesSirtuin 3Superoxide DismutaseSuperoxide Dismutase 2Reactive Oxygen SpeciesSirtuin 3Superoxide DismutaseSuperoxide Dismutase 2Cardiac-specific transgenic mouseMitochondriaMitochondrial translocationProtein acetylationProtein aggregationSOD2

Identifiers

PMID28433661
PMCPMC5487267
OpenAlexW2606259321

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.