Evidence map›Paper›PMID 28433549›Full record

ArticleThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2017

Influence of Negative Life Events and Widowhood on Risk for Dementia.

Lotte Gerritsen, Hui-Xin Wang, Chandra A Reynolds, Laura Fratiglioni, Margaret Gatz, Nancy L Pedersen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 2 pooled it
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.

  1. Is Stress an Overlooked Risk Factor for Dementia? A Systematic Review from a Lifespan Developmental Perspective.Prevention science : the official journal of the Society for Prevention Research · 2023
    Pooled it
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  8. Life Events and Incident Dementia: A Prospective Study of 493,787 Individuals Over 16 Years.The journals of gerontology. Series B, Psychological sciences and social sciences · 2024
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  12. Stressful life events, general cognitive performance, and financial capacity in healthy older adults and Alzheimer's disease patients.Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Osterreichischer Nervenarzte und Psychiater · 2023
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  16. Bayesian semi-parametric G-computation for causal inference in a cohort study with MNAR dropout and death.Journal of the Royal Statistical Society. Series C, Applied statistics · 2021
    Article
  17. Death of a Child Prior to Midlife, Dementia Risk, and Racial Disparities.The journals of gerontology. Series B, Psychological sciences and social sciences · 2020
    Article
  18. Article
  19. Stress and Alzheimer's disease: A senescence link?Neuroscience and biobehavioral reviews · 2020
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 3 countries.

Lotte GerritsenDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Clinical Psychology, Utrecht University, Utrecht, The Netherlands. Electronic address: lotte.gerritsen@ki.se.
Hui-Xin WangAging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet-Stockholm University, Stockholm, Sweden.
Chandra A ReynoldsDepartment of Psychology, University of California-Riverside, Riverside, CA.
Laura FratiglioniAging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet-Stockholm University, Stockholm, Sweden; Stockholm Gerontology Research Center, Stockholm, Sweden.
Margaret GatzDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Psychology, University of Southern California, Los Angeles, CA.
Nancy L PedersenDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Psychology, University of Southern California, Los Angeles, CA.
Karolinska Institutet · SEStockholm University · SEUniversity of California, Riverside · USUniversity of Southern California · USUtrecht University · NL

Funding

Gene-Environment Interplay of Social Contexts and Aging-Related OutcomesR01AG037985 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI PEDERSEN, NANCY L · 2010 to 2014
$3.2M
GENETIC &ENVIRONMENTAL INFLUENCES--BIOBEHAVIORAL AGINGR01AG010175 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI PEDERSEN, NANCY L · 1992 to 2006
$2.8M
DEMENTIA IN TWINSR01AG008724 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GATZ, MARGARET · 1990 to 2002
$1.4M
Dementia in Swedish Twins Data ArchivingR03AG031262 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GATZ, MARGARET · 2008 to 2008
$72k
NIA NIH HHS R01 AG008724NIA NIH HHS R01 AG010175NIA NIH HHS R01 AG037985NIA NIH HHS R03 AG031262
6 · The paper itself

Abstract

objectiveThe aim of the current study was to examine the effect of negative life events and widowhood on the incidence of dementia.

methodsData were from four Swedish longitudinal cohort studies with a total of nearly 2,000 participants and 8-25 years of follow-up. Seven stressful events were examined for which data were available in all cohorts. Clinical dementia diagnoses were made through medical and psychological examinations. Cox proportional hazards models were used to estimate the association between life events and dementia, adjusting for lifestyle and cardiovascular risk factors.

resultsThe experience of one stressful life event was not associated with dementia incidence, but two or more negative life events at baseline predicted higher risk for dementia (pooled HR: 2.00). This was most apparent for the incidence of vascular dementia (pooled HR: 3.60) but not for Alzheimer disease (pooled HR: 1.29). Moreover, persons who were widowed and had experienced one or more negative life events were found to have a threefold risk for dementia.

conclusionWidowhood augments the effect of negative life events on dementia incidence and negative life events specifically increase the risk for vascular dementia.

Indexed as

Life Change EventsAgedAged, 80 and overDementiaFemaleHumansLongitudinal StudiesMaleMiddle AgedRisk FactorsSwedenWidowhoodAlzheimer diseasedementiaold ageStressvascular dementia

Identifiers

PMID28433549
PMCPMC5474139
OpenAlexW2597136399

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.