Evidence map›Paper›PMID 28433449›Full record

Observational studyJournal of diabetes and its complications2017

Diabetes, depressive symptoms, and functional disability in African Americans: the Jackson Heart Study.

Rita Rastogi Kalyani, Nan Ji, Mercedes Carnethon, Alain G Bertoni, Elizabeth Selvin, Edward W Gregg, Mario Sims, Sherita Hill Golden

Open access · greenAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of diabetes and its complications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 7 institutions in 1 country.

Rita Rastogi KalyaniDepartment of Medicine, Johns Hopkins University School of Medicine, 1830 East Monument Street, Suite 333, Baltimore, MD 21287, USA; Welch Center for Prevention, Epidemiology, and Clinical Research, 2024 East Monument Street, Suite 333, Baltimore, MD 21287, USA. Electronic address: rrastogi@jhmi.edu.
Nan JiDepartment of Medicine, Johns Hopkins University School of Medicine, 1830 East Monument Street, Suite 333, Baltimore, MD 21287, USA. Electronic address: nancyji0702@gmail.com.
Mercedes CarnethonDepartment of Preventive Medicine-Epidemiology, Northwestern University Feinberg School of Medicine, 680 N Lake Shore Drive, Suite 1400, Chicago, IL 60611, USA. Electronic address: carnethon@northwestern.edu.
Alain G BertoniDepartment of Epidemiology and Prevention Wake Forest School of Medicine, 1 Medical Center Blvd, Winston-Salem, NC 27157, USA. Electronic address: abertoni@wfubmc.edu.
Elizabeth SelvinDepartment of Medicine, Johns Hopkins University School of Medicine, 1830 East Monument Street, Suite 333, Baltimore, MD 21287, USA; Welch Center for Prevention, Epidemiology, and Clinical Research, 2024 East Monument Street, Suite 333, Baltimore, MD 21287, USA. Electronic address: lselvin@jhsph.edu.
Edward W GreggCenters for Disease Control, Division of Diabetes Translation, 4770 Buford Hwy., NE Mailstop K-10, Atlanta, GA 30341, USA. Electronic address: edg7@cdc.gov.
Mario SimsDepartment of Medicine, University of Mississippi Medical Center, Jackson Medical Mall Suite 701, 350 W. Woodrow Wilson Drive, Jackson, MS 39213, USA. Electronic address: msims2@umc.edu.
Sherita Hill GoldenDepartment of Medicine, Johns Hopkins University School of Medicine, 1830 East Monument Street, Suite 333, Baltimore, MD 21287, USA; Welch Center for Prevention, Epidemiology, and Clinical Research, 2024 East Monument Street, Suite 333, Baltimore, MD 21287, USA. Electronic address: sahill@jhmi.edu.
Welch Foundation · USCenters for Disease Control and Prevention · USJohns Hopkins Medicine · USJohns Hopkins University · USNorthwestern University · USUniversity of Mississippi Medical Center · USWake Forest University · US

Funding

Targeted Analyses of Jackson Heart Study DataR01HL117285 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI BERTONI, ALAIN GERALD · 2013 to 2016
$941k
Research and Mentoring in the Clinical Epidemiology of Type 2 DiabetesK24DK106414 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SELVIN, ELIZABETH · 2015 to 2019
$654k
Glucose Insulin and Muscle LossK23DK093583 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI KALYANI, RITA R · 2012 to 2015
$635k
NHLBI NIH HHS HHSN268201300046CNHLBI NIH HHS HHSN268201300047CNHLBI NIH HHS HHSN268201300048CNHLBI NIH HHS HHSN268201300049CNHLBI NIH HHS HHSN268201300050CNHLBI NIH HHS R01 HL117285NIDDK NIH HHS K23 DK093583NIDDK NIH HHS K24 DK106414
6 · The paper itself

Abstract

aimsTo investigate the degree to which comorbid depression contributes to the relationship of diabetes with functional disability in African Americans (AAs), a population at high-risk for complications.

methodsWe examined 2989 African Americans (AAs) in the Jackson Heart Study who had diabetes and depressive symptoms (CES-D) assessed at baseline. Overall functional disability was defined as the inability to perform at least one task of daily living. Multivariable logistic regression models explored the association of diabetes and depressive symptoms with functional disability.

resultsPrevalence of overall functional disability was highest with both diabetes and depressive symptoms (54%), similar with diabetes alone (31%) or depressive symptoms alone (33%), and lowest with neither (15%). Adjusting for demographics, smoking, BMI, cardiovascular comorbidities, and hsCRP, the association of depressive symptoms alone (OR=2.30,95% CI 1.75-3.03) and both diabetes and depressive symptoms (OR=2.75,1.88-4.04) with overall functional disability was significant, but not for diabetes alone (OR=1.26,0.95-1.67), compared to neither. In regression analyses including any diabetes and any depressive symptoms together in models, the main effect of depressive symptoms but not diabetes was associated with overall functional disability, and the interaction term was not significant (p-value=0.84).

conclusionsFunctional disability was highest among AAs who have both diabetes and depressive symptoms; the latter was a stronger contributor. Future studies should explore mechanisms underlying functional disability in diabetes, particularly the role of depression.

Indexed as

Activities of Daily LivingCost of IllnessAdultAgedBlack or African AmericanCohort StudiesComorbidityCross-Sectional StudiesDiabetes MellitusFemaleFollow-Up StudiesHealth Status DisparitiesHumansMajor Depressive DisorderMaleMiddle AgedAfrican AmericansDepressionDiabetesFunctional disabilityRacial disparities

Identifiers

PMID28433449
PMCPMC5676306
OpenAlexW2594797904

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.