ArticleJournal of the American Academy of Child and Adolescent Psychiatry2017
Parental Age and Offspring Psychopathology in the Philadelphia Neurodevelopmental Cohort.
Article in Journal of the American Academy of Child and Adolescent Psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Parental Age and the Risk of ADHD in Offspring: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2021Pooled it
- Associations Between Teenage Motherhood, Perinatal Cortical Maturation, and Risk of Psychopathology in Children: The Mediating Role of Pregnancy Complications.Biological psychiatry global open science · 2026Article
- Article
- Mapping corpus callosum architecture: developmental, genetic, and cognitive correlates in youth.bioRxiv : the preprint server for biology · 2026Article
- The Impact of Sociodemographic Factors on Job Insecurity Among Obstetric Nurses Under the Low Fertility Background: A Linear Mixed-Effects Model Analysis and Targeted Intervention Strategies.Journal of multidisciplinary healthcare · 2026Article
- Effect of Parental-Child Age Gaps and Skipped-Generation Families on Comorbidities Related to Attention Deficit Hyperactivity Disorder: A Population-Based Case-Control Study.Children (Basel, Switzerland) · 2025Article
- Environmental factors associated with autism spectrum disorder in Southern Europe: a systematic review.International journal of developmental disabilities · 2025Review
- The Association Between Age at First Live Birth and Depression: Results From NHANES 2005-2018.Depression and anxiety · 2025Article
- Maternal Eating Disorders, Body Mass Index, and Offspring Psychiatric Diagnoses.JAMA network open · 2024Article
- How can China tackle its declining fertility rate?BMJ (Clinical research ed.) · 2024Article
- Association of Paternal Age Alone and Combined with Maternal Age with Perinatal Outcomes: A Prospective Multicenter Cohort Study in China.Journal of epidemiology and global health · 2024Observational
- Inter and transgenerational impact of H3K4 methylation in neuronal homeostasis.Life science alliance · 2023Article
- Behavioral and neurostructural correlates of childhood physical violence victimization: Interaction with family functioning.Developmental psychobiology · 2023Article
- Hair Trace Elements and Mineral Content in Moroccan Children with Autism Spectrum Disorder: a Case-Control Study.Biological trace element research · 2023Article
- Building a family at advanced parental age: a systematic review on the risks and opportunities for parents and their offspring.Human reproduction open · 2023Review
- Effect of advanced parental age on pregnancy outcome and offspring health.Journal of assisted reproduction and genetics · 2022Review
- Association between paternal age at childbirth and autism spectrum disorder in offspring.Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2022Article
- Familial clustering of birth risk for adverse childhood outcomes.Journal of perinatology : official journal of the California Perinatal Association · 2022Article
- A multifactorial model for the etiology of neuropsychiatric disorders: the role of advanced paternal age.Pediatric research · 2022Review
- Modeling familial predictors of proband outcomes in neurogenetic disorders: initial application in XYY syndrome.Journal of neurodevelopmental disorders · 2021Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveIncreasing evidence implicates advanced paternal age at offspring birth in neuropsychiatric disorders. Advanced maternal age has also been associated with schizophrenia and other neurodevelopmental disorders, whereas younger maternal age has been linked with behavioral disorders. Few studies have considered the specificity of the associations with respect to comorbidity. In addition, most prior studies have been conducted in clinical samples or registries that may reflect more severe forms of psychopathology. The aim of this research is to examine the independent and joint associations of maternal and paternal age with specific subtypes of psychopathology in offspring in a pediatric sample of adolescents with emergent psychiatric syndromes.
methodA total of 8,725 youths (aged 8-21 years) from the Philadelphia Neurodevelopmental Cohort were included in the analyses. Logistic regression models with parental age predicting offspring psychopathology were adjusted for sociodemographic factors and comorbid disorders.
resultsWe found that younger parental ages were generally associated with increased rates of offspring psychopathology. After controlling for sociodemographic characteristics and comorbidity, both younger maternal and paternal ages were associated with behavior syndromes and psychosis in youth, whereas advanced paternal age was associated with pervasive developmental disorders/autism spectrum disorder (PDD/ASD).
conclusionThese findings suggest that both younger and older parental age at birth are associated with specific forms of psychopathology in offspring. The persistence of the influence of parental age after control for demographic factors and an index of social environment suggests that additional explanations for these findings should be examined in future studies.
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