Evidence map›Paper›PMID 28433069›Full record

ArticleThe Kaohsiung journal of medical sciences2017

Assessment of therapeutic effect of human choriogonadotropin in a chemical cystitis model.

Serhat Tanik, Kürsad Zengin, Sebahattin Albayrak, Abdullah Gurel, Muhittin Atar, Sevinc Sahin, Nevin Tuzcu, Mehmet Tuzcu, Muhammet Abdurrahim Imamoglu, Mesut Gurdal

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Kaohsiung journal of medical sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 96% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Serhat TanikDepartment of Urology, Bozok University, School of Medicine, Yozgat, Turkey. Electronic address: tanikserhat@gmail.com.
Kürsad ZenginDepartment of Urology, Afyon Kocatepe University, School of Medicine, Afyon, Turkey.
Sebahattin AlbayrakDepartment of Urology, Bozok University, School of Medicine, Yozgat, Turkey.
Abdullah GurelDepartment of Urology, Bozok University, School of Medicine, Yozgat, Turkey.
Muhittin AtarDepartment of Urology, Bozok University, School of Medicine, Yozgat, Turkey.
Sevinc SahinDepartment of Pathology, Bozok University, School of Medicine, Yozgat, Turkey.
Nevin TuzcuDepartment of Pharmaceutical Microbiology, Cumhuriyet University, Faculty of Pharmacy, Sivas, Turkey.
Mehmet TuzcuDepartment of Pathology, Cumhuriyet University, Faculty of Veterinary Medicine, Sivas, Turkey.
Muhammet Abdurrahim ImamogluDepartment of Urology, Bozok University, School of Medicine, Yozgat, Turkey.
Mesut GurdalDepartment of Urology, Bozok University, School of Medicine, Yozgat, Turkey.
Bozok Universitesi · TRSivas Cumhuriyet Üniversitesi · TRAfyon Kocatepe University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, female rats induced with chemical cystitis were administered the hormone human choriogonadotropin (HCG), and it was aimed to reveal the usefulness of HCG in the treatment of interstitial cystitis/bladder pain syndrome. The materials for this study were 32 Wistar albino female rats. The study groups were formed as follows: the cystitis group (Group 1), the cystitis + HCG protection group (Group 2), the cystitis + HCG treatment group (Group 3), and the control group (Group 4), with eight rats in each group. In this study, blood and urine samples were taken from the rats, they were euthanized, and their bladders were removed for glutathione, malondialdehyde, tumor necrosis factor alpha, and interferon gamma measurements. It was observed that tissue damage in Group 2 was lower than that in the other two groups. Glutathione levels in Groups 2 and 4 were significantly higher than in Groups 1 and 3 (p = 0.01). Malondialdehyde levels of Groups 2 and 4 were significantly lower than the values in Groups 1 and 3 (p < 0.001). When the cystitis groups were compared in terms of their interferon gamma and tumor necrosis factor alpha levels, the lowest interferon gamma and tumor necrosis factor alpha levels were detected in Group 3. It was found that HCG has positive effects on experimental cystitis in rats. This study revealed that HCG should be researched as a therapeutic agent and formed a step for studies to be carried out on this subject.

Indexed as

AnimalsChorionic GonadotropinCystitisDisease Models, AnimalFemaleGlutathioneHumansInterferon-gammaMalondialdehydeRatsTumor Necrosis Factor-alphaUrinary Bladder DiseasesChorionic GonadotropinGlutathioneInterferon-gammaMalondialdehydeTumor Necrosis Factor-alphaBladder pain syndromeCyclophosphamideHuman choriogonadotropinInterstitial cystitisRat

Identifiers

PMID28433069
PMCPMC11916625
OpenAlexW2598181285

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.