ArticleIranian biomedical journal2017
Plackett-Burman Design and Response Surface Optimization of Medium Trace Nutrients for Glycolipopeptide Biosurfactant Production
Article in Iranian biomedical journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed.
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- Optimization, purification, and characterization of xylanase production by a newly isolated Trichoderma harzianum strain by a two-step statistical experimental design strategy.Scientific reports · 2022Article
- Bioprocess development as a sustainable platform for eco-friendly alkaline phosphatase production: an approach towards crab shells waste management.Microbial cell factories · 2022Article
- A novel strain of Stenotrophomonas acidaminiphila produces thermostable alkaline peptidase on agro-industrial wastes: process optimization, kinetic modeling and scale-up.Archives of microbiology · 2022Article
- Development of a New Bioprocess for Clean Diosgenin Production through Submerged Fermentation of an Endophytic Fungus.ACS omega · 2021Article
- Bioprocess Optimization of Nutritional Parameters for Enhanced Anti-leukemic L-Asparaginase Production byInternational journal of peptide research and therapeutics · 2021Article
- Statistical and Artificial Neural Network Approaches to Modeling and Optimization of Fermentation Conditions for Production of a Surface/Bioactive Glyco-lipo-peptide.International journal of peptide research and therapeutics · 2021Article
- Application of statistical design to evaluate critical process parameters and optimize formulation technique of polymeric nanoparticles.Royal Society open science · 2019Article
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- A serum-free medium suitable for maintaining cell morphology and liver-specific function in induced human hepatocytes.Cytotechnology · 2019Article
- Simultaneous elimination of Malachite Green, Rhodamine B and Cresol Red from aqueous sample with Sistan sand, optimized by Taguchi L16 and Plackett-Burman experiment design methods.Chemistry Central journal · 2018Article
- Optimization of Cultural Conditions forBioMed research international · 2018Article
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4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Background: A glycolipopeptide biosurfactant produced by Pseudomonas aeruginosa strain IKW1 reduced the surface tension of fermentation broth from 71.31 to 24.62 dynes/cm at a critical micelle concentration of 20.80 mg/L. The compound proved suitable for applications in emulsion stabilization in food, as well as in cosmetic and pharmaceutical formulations. Method: In the present study, Plackett-Burman design (PBD) and response surface method (RSM) were employed to screen and optimize concentrations of trace nutrients in the fermentation medium, to increase surfactant yield. Results: The PBD selected 5 out of the 12 screened significant trace nutrients. The RSM, on the other hand, resulted in the production of 84.44 g glycolipopeptide/L in the optimized medium containing 1.25 mg/L nickel, 0.125 mg/L zinc, 0.075 mg/L iron, 0.0104 mg/L boron, and 0.025 mg/L copper. Conclusion: Significant second-order quadratic models for biomass (P<0.05; adjusted R2=94.29%) and biosurfactant (R2=99.44%) responses suggest excellent goodness-of-fit of the models. However, their respective non-significant lack-of-fit (Biomass: F=1.28; P=0.418; Biosurfactant: F=1.20; P=0.446) test results indicate their adequacy to explain data variations in the experimental region. The glycolipopeptide is recommended for the formulation of inexpensive pharmaceutical products that require surface-active compounds.
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