Evidence map›Paper›PMID 28432987›Full record

ArticleBrain and language2017

Multimodal imaging of language reorganization in patients with left temporal lobe epilepsy.

Yu-Hsuan A Chang, Nobuko Kemmotsu, Kelly M Leyden, N Erkut Kucukboyaci, Vicente J Iragui, Evelyn S Tecoma, Leena Kansal, Marc A Norman, Rachelle Compton, Tobin J Ehrlich and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain and language, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Neurobehavioral and Clinical Comorbidities in Epilepsy: The Role of White Matter Network Disruption.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2024
    Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
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  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yu-Hsuan A ChangCenter for Multimodal Imaging and Genetics, University of California - San Diego, 9452 Medical Center Drive, La Jolla, CA 92037, USA; Department of Psychiatry, University of California - San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA. Electronic address: yuc023@ucsd.edu.
Nobuko KemmotsuDepartment of Psychiatry, University of California - San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA. Electronic address: nkemmotsu@ucsd.edu.
Kelly M LeydenDepartment of Psychiatry, University of California - San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA. Electronic address: kmleyden@gmail.com.
N Erkut KucukboyaciSDSU/UC San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA. Electronic address: erkut@ucsd.edu.
Vicente J IraguiDepartment of Neurosciences, University of California - San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA. Electronic address: viragui@ucsd.edu.
Evelyn S TecomaDepartment of Neurosciences, University of California - San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA. Electronic address: etecoma@ucsd.edu.
Leena KansalDepartment of Neurosciences, University of California - San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA. Electronic address: lkansal@ucsd.edu.
Marc A NormanDepartment of Psychiatry, University of California - San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA. Electronic address: mnorman@ucsd.edu.
Rachelle ComptonDepartment of Neurosciences, University of California - San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA. Electronic address: rcompton@ucsd.edu.
Tobin J EhrlichPalo Alto University, 1971 Arastradero Drive, Palo Alto, CA 94304, USA. Electronic address: tehrlich@paloaltou.edu.
Vedang S UttarwarCenter for Multimodal Imaging and Genetics, University of California - San Diego, 9452 Medical Center Drive, La Jolla, CA 92037, USA; Department of Psychiatry, University of California - San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA. Electronic address: vuttarwar@ucsd.edu.
Anny ReyesCenter for Multimodal Imaging and Genetics, University of California - San Diego, 9452 Medical Center Drive, La Jolla, CA 92037, USA; Department of Psychiatry, University of California - San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA; SDSU/UC San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA. Electronic address: anr086@ucsd.edu.
Brianna M PaulDepartment of Neurology, University of California - San Francisco, San Francisco, CA, USA; UCSF Comprehensive Epilepsy Center, San Francisco, CA, USA. Electronic address: Brianna.Paul@ucsf.edu.
Carrie R McDonaldCenter for Multimodal Imaging and Genetics, University of California - San Diego, 9452 Medical Center Drive, La Jolla, CA 92037, USA; Department of Psychiatry, University of California - San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA; SDSU/UC San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA. Electronic address: camcdonald@ucsd.edu.

Funding

Multimodal Imaging of Language in the Preoperative Evaluation of EpilepsyR01NS065838 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MCDONALD, CARRIE R · 2010 to 2018
$4.4M
NINDS NIH HHS R01 NS065838
6 · The paper itself

Abstract

This study explored the relationships among multimodal imaging, clinical features, and language impairment in patients with left temporal lobe epilepsy (LTLE). Fourteen patients with LTLE and 26 controls underwent structural MRI, functional MRI, diffusion tensor imaging, and neuropsychological language tasks. Laterality indices were calculated for each imaging modality and a principal component (PC) was derived from language measures. Correlations were performed among imaging measures, as well as to the language PC. In controls, better language performance was associated with stronger left-lateralized temporo-parietal and temporo-occipital activations. In LTLE, better language performance was associated with stronger right-lateralized inferior frontal, temporo-parietal, and temporo-occipital activations. These right-lateralized activations in LTLE were associated with right-lateralized arcuate fasciculus fractional anisotropy. These data suggest that interhemispheric language reorganization in LTLE is associated with alterations to perisylvian white matter. These concurrent structural and functional shifts from left to right may help to mitigate language impairment in LTLE.

Indexed as

LanguageMultimodal ImagingAdultAnisotropyBrain MappingCerebral CortexDiffusion Tensor ImagingEpilepsy, Temporal LobeFemaleFunctional LateralityHumansLanguage DisordersMagnetic Resonance ImagingMaleMiddle AgedNerve NetCortical thicknessDTIFunctional MRILanguageTemporal lobe epilepsy

Identifiers

PMID28432987
PMCPMC5507363

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.