ReviewMolecular and cellular pediatrics2017
Human perinatal immunity in physiological conditions and during infection.
Review in Molecular and cellular pediatrics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 3 syntheses or guidelines pooled it, 83 citations in OpenAlex.
- The effect of intrapartum maternal fever on neonatal outcomes: a systematic review and meta-analysis.Frontiers in pediatrics · 2025Pooled it
- Maternal and perinatal outcomes with COVID-19: A systematic review of 108 pregnancies.Acta obstetricia et gynecologica Scandinavica · 2020Pooled it
- Association of Histological and Clinical Chorioamnionitis With Neonatal Sepsis Among Preterm Infants: A Systematic Review, Meta-Analysis, and Meta-Regression.Frontiers in immunology · 2020Pooled it
- Incidence and Clinical Outcomes of Premature Infants: 1-Year Retrospective Study at the NICU of Gadarif Teaching Hospital.Health science reports · 2026Article
- Fetal and Neonatal Immune Response to Congenital Cytomegalovirus (cCMV) Infection: A Systematically Conducted Scoping Review.Viruses · 2026Article
- Neonatal mpox in Nigeria: a case of transplacental or postnatal transmission.BMC infectious diseases · 2025Article
- Delivery room resuscitation and short-term outcomes in very preterm infants: a multicenter cross-sectional study in China.Frontiers in pediatrics · 2024Article
- Article
- Article
- Prevalence of anti-leptospiral IgM and detection of pathogenic Leptospira species DNA in neonates presenting with clinical sepsis in Southwestern Uganda.European journal of medical research · 2022Article
- Immediate to short-term inflammatory response to biomaterial implanted in calvarium of mice.European journal of translational myology · 2022Article
- Prevalence of SARS-CoV-2 infection in neonates born to mothers or relatives with COVID-19.BMC infectious diseases · 2022Article
- Prenatal administration of multipotent adult progenitor cells modulates the systemic and cerebral immune response in an ovine model of chorioamnionitis.Brain, behavior, & immunity - health · 2022Article
- Neurodevelopmental outcomes of infants born to mothers with SARS-CoV-2 infections during pregnancy: a national prospective study in Kuwait.BMC pediatrics · 2022Article
- Effects of COVID-19 during pregnancy on maternal and neonatal outcome: A retrospective observational study in tertiary teaching hospital, India.Journal of family medicine and primary care · 2022Article
- Retinal and Choroidal Pathologies in Aged BALB/c Mice Following Systemic Neonatal Murine Cytomegalovirus Infection.The American journal of pathology · 2021Article
- The impact of COVID-19 during pregnancy on maternal and neonatal outcomes: a systematic review.EMBnet.journal · 2021Article
- Review
- The immunological link between neonatal lung and eye disease.Clinical & translational immunology · 2021Review
- Understanding Host-Pathogen Interactions in Acute Chorioamnionitis Through the Use of Animal Models.Frontiers in cellular and infection microbiology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The intrauterine environment was long considered sterile. However, several infectious threats are already present during fetal life. This review focuses on the postnatal immunological consequences of prenatal exposure to microorganisms and related inflammatory stimuli. Both the innate and adaptive immune systems of the fetus and neonate are immature, which makes them highly susceptible to infections. There is good evidence that prenatal infections are a primary cause of preterm births. Additionally, the association between antenatal inflammation and adverse neonatal outcomes has been well established. The lung, gastrointestinal tract, and skin are exposed to amniotic fluid during pregnancy and are probable targets of infection and subsequent inflammation during pregnancy. We found a large number of studies focusing on prenatal infection and the host response. Intrauterine infection and fetal immune responses are well studied, and we describe clinical data on cellular, cytokine, and humoral responses to different microbial challenges. The link to postnatal immunological effects including immune paralysis and/or excessive immune activation, however, turned out to be much more complicated. We found studies relating prenatal infectious or inflammatory hits to well-known neonatal diseases such as respiratory distress syndrome, bronchopulmonary dysplasia, and necrotizing enterocolitis. Despite these data, a direct link between prenatal hits and postnatal immunological outcome could not be undisputedly established. We did however identify several unresolved topics and propose questions for further research.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.