Evidence map›Paper›PMID 28432663›Full record

ReviewCurrent cardiology reports2017

The Vascular Wall: a Plastic Hub of Activity in Cardiovascular Homeostasis and Disease.

Cassandra P Awgulewitsch, Linh T Trinh, Antonis K Hatzopoulos

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current cardiology reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Cassandra P AwgulewitschDivision of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, 2213 Garland Avenue, Nashville, TN, 37232-6300, USA.
Linh T TrinhDivision of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, 2213 Garland Avenue, Nashville, TN, 37232-6300, USA.
Antonis K HatzopoulosDivision of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, 2213 Garland Avenue, Nashville, TN, 37232-6300, USA. antonis.hatzopoulos@vanderbilt.edu.

Funding

Optimizing Cardiovascular Stem Cells for Cardiac Repair and RegenerationU01HL100398 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HATZOPOULOS, ANTONIS · 2009 to 2015
$8.0M
Optimizing Cardiovascular Stem Cells for Cardiac RepairR03HL096266 · NHLBI · VANDERBILT UNIVERSITY · PI HATZOPOULOS, ANTONIS · 2009 to 2009
$38k
NHLBI NIH HHS R03 HL096266NHLBI NIH HHS U01 HL100398
6 · The paper itself

Abstract

purpose of reviewThis review aims to summarize recent findings regarding the plasticity and fate switching among somatic and progenitor cells residing in the vascular wall of blood vessels in health and disease. RECENT

findingsCell lineage tracing methods have identified multiple origins of stem cells, macrophages, and matrix-producing cells that become mobilized after acute or chronic injury of cardiovascular tissues. These studies also revealed that in the disease environment, resident somatic cells become plastic, thereby changing their stereotypical identities to adopt proinflammatory and profibrotic phenotypes. Currently, the functional significance of this heterogeneity among reparative cells is unknown. Furthermore, mechanisms that control cellular plasticity and fate decisions in the disease environment are poorly understood. Cardiovascular diseases are responsible for the majority of deaths worldwide. From a therapeutic perspective, these novel discoveries may identify new targets to improve the repair and regeneration of the cardiovascular system.

Indexed as

Cell PlasticityBlood VesselsCardiovascular DiseasesCell DifferentiationCell LineageEpithelial-Mesenchymal TransitionHomeostasisHumansStem CellsCardiovascular homeostasisCellular plasticityEndothelial-to-mesenchymal transitionPerivascular cellsStem cellsVascular wall

Identifiers

PMID28432663

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.