Evidence map›Paper›PMID 28432448›Full record

ArticleBiomechanics and modeling in mechanobiology2017

Resistance to radial expansion limits muscle strain and work.

E Azizi, A R Deslauriers, N C Holt, C E Eaton

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomechanics and modeling in mechanobiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
6.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 77 citations in OpenAlex.

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  19. Age-Related Changes in the Matrisome of the Mouse Skeletal Muscle.International journal of molecular sciences · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

E AziziDepartment of Ecology and Evolutionary Biology, University of California, 321 Steinhaus Hall, Irvine, CA, 92697, USA. eazizi@uci.edu.ORCID http://orcid.org/0000-0001-7338-8673
A R DeslauriersDepartment of Ecology and Evolutionary Biology, University of California, 321 Steinhaus Hall, Irvine, CA, 92697, USA.
N C HoltDepartment of Ecology and Evolutionary Biology, University of California, 321 Steinhaus Hall, Irvine, CA, 92697, USA.
C E EatonDepartment of Ecology and Evolutionary Biology, University of California, 321 Steinhaus Hall, Irvine, CA, 92697, USA.
University of California, Irvine · US

Funding

Elastic mechanisms in locomotionR01AR055295 · NIAMS · BROWN UNIVERSITY · PI EMANUEL AZIZI, Thomas Jay Roberts · 2008 to 2026
$6.0M
National Institute of Arthritis and Musculoskeletal and Skin Diseases AR055295National Science Foundation #1436476NIAMS NIH HHS R01 AR055295
6 · The paper itself

Abstract

The collagenous extracellular matrix (ECM) of skeletal muscle functions to transmit force, protect sensitive structures, and generate passive tension to resist stretch. The mechanical properties of the ECM change with age, atrophy, and neuromuscular pathologies, resulting in an increase in the relative amount of collagen and an increase in stiffness. Although numerous studies have focused on the effect of muscle fibrosis on passive muscle stiffness, few have examined how these structural changes may compromise contractile performance. Here we combine a mathematical model and experimental manipulations to examine how changes in the mechanical properties of the ECM constrain the ability of muscle fibers and fascicles to radially expand and how such a constraint may limit active muscle shortening. We model the mechanical interaction between a contracting muscle and the ECM using a constant volume, pressurized, fiber-wound cylinder. Our model shows that as the proportion of a muscle cross section made up of ECM increases, the muscle's ability to expand radially is compromised, which in turn restricts muscle shortening. In our experiments, we use a physical constraint placed around the muscle to restrict radial expansion during a contraction. Our experimental results are consistent with model predictions and show that muscles restricted from radial expansion undergo less shortening and generate less mechanical work under identical loads and stimulation conditions. This work highlights the intimate mechanical interaction between contractile and connective tissue structures within skeletal muscle and shows how a deviation from a healthy, well-tuned relationship can compromise performance.

Indexed as

Stress, MechanicalAnimalsBiomechanical PhenomenaModels, BiologicalMuscle ContractionMuscle, SkeletalRanidaeCollagenECMIntramuscular pressureMuscleMuscle fibrosis

Identifiers

PMID28432448
PMCPMC5889119
OpenAlexW2606293300

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.