ArticleScientific reports2017
Differential sensitivity to infections and antimicrobial peptide-mediated immune response in four silkworm strains with different geographical origin.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Host-associated beneficial gut microbiota boosts induced immunity and limits immune deployment costs in bumblebees.The Journal of animal ecology · 2026Article
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- Genetic and morphological variation in the Colombian Bombyx mori germplasm: A first SSR-based assessment.PloS one · 2025Article
- Pathogenicity and host-interacting mechanisms of enterogenicFrontiers in microbiology · 2025Article
- FightingInternational journal of molecular sciences · 2023Article
- Cecropin D-derived synthetic peptides in the fight againstFrontiers in microbiology · 2022Article
- Mechanical Processing ofAnimals : an open access journal from MDPI · 2021Article
- A Silkworm Infection Model for In Vivo Study of Glycopeptide Antibiotics.Antibiotics (Basel, Switzerland) · 2020Article
- Silkworm pupae as source of high-value edible proteins and of bioactive peptides.Food science & nutrition · 2020Article
- Antimicrobial peptides fromRSC advances · 2019Review
- Insect Cecropins, Antimicrobial Peptides with Potential Therapeutic Applications.International journal of molecular sciences · 2019Review
- Sarconesin II, a New Antimicrobial Peptide Isolated fromMolecules (Basel, Switzerland) · 2019Article
- Intrinsic antimicrobial properties of silk spun by genetically modified silkworm strains.Transgenic research · 2018Article
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8 authors.
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Abstract
The domesticated silkworm Bombyx mori has an innate immune system, whose main effectors are the antimicrobial peptides (AMPs). Silkworm strains are commonly grouped into four geographical types (Japanese, Chinese, European and Tropical) and are generally characterised by a variable susceptibility to infections. To clarify the genetic and molecular mechanisms on which the different responses to infections are based, we exposed one silkworm strain for each geographical area to oral infections with the silkworm pathogens Enterococcus mundtii or Serratia marcescens. We detected a differential susceptibility to both bacteria, with the European strain displaying the lowest sensitivity to E. mundtii and the Indian one to S. marcescens. We found that all the strains were able to activate the AMP response against E. mundtii. However, the highest tolerance of the European strain appeared to be related to the specific composition of its AMP cocktail, containing more effective variants such as a peculiar Cecropin B6 isoform. The resistance of the Indian strain to S. marcescens seemed to be associated with its prompt capability to activate the systemic transcription of AMPs. These data suggest that B. mori strains with distinct genetic backgrounds employ different strategies to counteract bacterial infections, whose efficacy appears to be pathogen-dependent.
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