ArticleScientific reports2017
Closed-loop deep brain stimulation by pulsatile delayed feedback with increased gap between pulse phases.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Delay suppression control of β-oscillations: a proposal for dual-target adaptive deep brain stimulation on STN-GPe network model.Biological cybernetics · 2025Article
- Cortico-thalamic tremor circuits and their associations with deep brain stimulation effects in essential tremor.Brain : a journal of neurology · 2025Article
- Synaptic reorganization of synchronized neuronal networks with synaptic weight and structural plasticity.PLoS computational biology · 2024Article
- Feedback control of collective dynamics in an oscillator population with time-dependent connectivity.Frontiers in network physiology · 2024Article
- Machine learning for adaptive deep brain stimulation in Parkinson's disease: closing the loop.Journal of neurology · 2023Review
- Improved control effect of pathological oscillations by using delayed feedback stimulation in neural mass model with pedunculopontine nucleus.Brain and behavior · 2023Article
- Improving Visual Working Memory with Cholinergic Deep Brain Stimulation.Brain sciences · 2023Review
- Decoupling of interacting neuronal populations by time-shifted stimulation through spike-timing-dependent plasticity.PLoS computational biology · 2023Article
- Suppression of seizure in childhood absence epilepsy using robust control of deep brain stimulation: a simulation study.Scientific reports · 2023Article
- Efficient suppression of parkinsonian beta oscillations in a closed-loop model of deep brain stimulation with amplitude modulation.Frontiers in human neuroscience · 2022Article
- Robust multi-input multi-output adaptive fuzzy terminal sliding mode control of deep brain stimulation in Parkinson's disease: a simulation study.Scientific reports · 2021Article
- Optimizing deep brain stimulation based on isostable amplitude in essential tremor patient models.Journal of neural engineering · 2021Article
- Technology of deep brain stimulation: current status and future directions.Nature reviews. Neurology · 2021Review
- Safety and Tolerability of Burst-Cycling Deep Brain Stimulation for Freezing of Gait in Parkinson's Disease.Frontiers in human neuroscience · 2021Article
- Long-Lasting Desynchronization Effects of Coordinated Reset Stimulation Improved by Random Jitters.Frontiers in physiology · 2021Article
- Adaptive Parameter Modulation of Deep Brain Stimulation Based on Improved Supervisory Algorithm.Frontiers in neuroscience · 2021Article
- Cholinergic Deep Brain Stimulation for Memory and Cognitive Disorders.Journal of Alzheimer's disease : JAD · 2021Review
- Differential Effects of Open- and Closed-Loop Intracortical Microstimulation on Firing Patterns of Neurons in Distant Cortical Areas.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Multi-Dimensional, Short-Timescale Quantification of Parkinson's Disease and Essential Tremor Motor Dysfunction.Frontiers in neurology · 2020Article
- Long-Lasting Desynchronization of Plastic Neural Networks by Random Reset Stimulation.Frontiers in physiology · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Computationally it was shown that desynchronizing delayed feedback stimulation methods are effective closed-loop techniques for the control of synchronization in ensembles of interacting oscillators. We here computationally design stimulation signals for electrical stimulation of neuronal tissue that preserve the desynchronizing delayed feedback characteristics and comply with mandatory charge deposit-related safety requirements. For this, the amplitude of the high-frequency (HF) train of biphasic charge-balanced pulses used by the standard HF deep brain stimulation (DBS) is modulated by the smooth feedback signals. In this way we combine the desynchronizing delayed feedback approach with the HF DBS technique. We show that such a pulsatile delayed feedback stimulation can effectively and robustly desynchronize a network of model neurons comprising subthalamic nucleus and globus pallidus external and suggest this approach for desynchronizing closed-loop DBS. Intriguingly, an interphase gap introduced between the recharging phases of the charge-balanced biphasic pulses can significantly improve the stimulation-induced desynchronization and reduce the amount of the administered stimulation. In view of the recent experimental and clinical studies indicating a superiority of the closed-loop DBS to open-loop HF DBS, our results may contribute to a further development of effective stimulation methods for the treatment of neurological disorders characterized by abnormal neuronal synchronization.
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