ArticleScientific reports2017
Overexpression of human NR2B receptor subunit in LMAN causes stuttering and song sequence changes in adult zebra finches.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- Differential morphology and distribution of GFAP astrocytes in vocal brain circuit in a songbird Southern house wren and humans.Frontiers in neuroanatomy · 2026Article
- Challenges and Opportunities in Characterizing the Genetics of Stuttering: From Sample Acquisition to Functional Interpretation of the Genome.Journal of speech, language, and hearing research : JSLHR · 2025Review
- GluN2B mRNA expression and molecular sequence in the brain of pigeons (Journal of advanced veterinary and animal research · 2025Article
- Stuttering: Our Current Knowledge, Research Opportunities, and Ways to Address Critical Gaps.Neurobiology of language (Cambridge, Mass.) · 2025Review
- A versatile pipeline to identify convergently lost ancestral conserved fragments associated with convergent evolution of vocal learning.Briefings in bioinformatics · 2024Article
- Analogies of human speech and bird song: From vocal learning behavior to its neural basis.Frontiers in psychology · 2023Review
- Dopamine, vocalization, and astrocytes.Brain and language · 2021Article
- Divergent low-density lipoprotein receptor (LDLR) linked to low VSV G-dependent viral infectivity and unique serum lipid profile in zebra finches.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Blocking Opioid Receptors in a Songbird Cortical Region Modulates the Acoustic Features and Levels of Female-Directed Singing.Frontiers in neuroscience · 2020Article
- Involvement of the Cortico-Basal Ganglia-Thalamocortical Loop in Developmental Stuttering.Frontiers in psychology · 2019Review
- Divergence in problem-solving skills is associated with differential expression of glutamate receptors in wild finches.Science advances · 2018Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Zebra finches (Taeniopygia guttata) learn to produce songs in a manner reminiscent of spoken language development in humans. One candidate gene implicated in influencing learning is the N-methyl-D-aspartate (NMDA) subtype 2B glutamate receptor (NR2B). Consistent with this idea, NR2B levels are high in the song learning nucleus LMAN (lateral magnocellular nucleus of the anterior nidopallium) during juvenile vocal learning, and decreases to low levels in adults after learning is complete and the song becomes more stereotyped. To test for the role of NR2B in generating song plasticity, we manipulated NR2B expression in LMAN of adult male zebra finches by increasing its protein levels to those found in juvenile birds, using a lentivirus containing the full-length coding sequence of the human NR2B subunit. We found that increased NR2B expression in adult LMAN induced increases in song sequence diversity and slower song tempo more similar to juvenile songs, but also increased syllable repetitions similar to stuttering. We did not observe these effects in control birds with overexpression of NR2B outside of LMAN or with the green fluorescent protein (GFP) in LMAN. Our results suggest that low NR2B subunit expression in adult LMAN is important in conserving features of stereotyped adult courtship song.
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