Evidence map›Paper›PMID 28432198›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2017

Folate-dependent methylation of septins governs ciliogenesis during neural tube closure.

Manami Toriyama, Michinori Toriyama, John B Wallingford, Richard H Finnell

Open access · bronzeAbstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
4.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 39 citations in OpenAlex.

  1. Review
  2. bioRxiv : the preprint server for biology · 2025
    Article
  3. Article
  4. Review
  5. Maternal metabolism influences neural tube closure.Trends in endocrinology and metabolism: TEM · 2023
    Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. Homocysteine Metabolism in Pregnancy and Developmental Impacts.Frontiers in cell and developmental biology · 2022
    Review
  11. Review
  12. Review
  13. Primary Cilia in the Skin: Functions in Immunity and Therapeutic Potential.Frontiers in cell and developmental biology · 2021
    Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Manami ToriyamaDepartment of Pediatrics, Dell Pediatric Research Institute, The University of Texas at Austin Dell Medical School, Austin, Texas, USA.
Michinori ToriyamaDepartment of Molecular Biosciences, The University of Texas at Austin, Austin, Texas, USA.
John B WallingfordDepartment of Molecular Biosciences, The University of Texas at Austin, Austin, Texas, USA.
Richard H FinnellDepartment of Pediatrics, Dell Pediatric Research Institute, The University of Texas at Austin Dell Medical School, Austin, Texas, USA; rfinnell@austin.utexas.edu.
DELL (United States) · USOsaka University of Pharmaceutical Sciences · JPThe University of Texas at Austin · US

Funding

Risk Genes and Environment Interactions in NTDsP01HD067244 · NICHD · WEILL MEDICAL COLL OF CORNELL UNIV · PI ROSS, MARGARET ELIZABETH · 2011 to 2020
$12.6M
Mapping the CPLANE interactome, an extensive protein interaction network underlying human ciliopathiesR01HD085901 · NICHD · UNIVERSITY OF TEXAS AT AUSTIN · PI EDWARD M MARCOTTE, John B Wallingford · 2016 to 2026
$6.2M
Epigenome Interactions in Complex Neurogenetic DisordersR01NS076465 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI MASON, CHRISTOPHER EDWARD, ROSS, MARGARET ELIZABETH · 2011 to 2015
$5.8M
INTERVENTION STRATEGIES FOR NON-FOLATE RESPONSIVE NEURAL TUBE DEFECTSR01HD083809 · NICHD · UNIVERSITY OF TEXAS AT AUSTIN · PI FINNELL, RICHARD H. · 2016 to 2024
$5.1M
Folic Acid, Parental Mutation Rates and the Risk for Neural Tube DefectsR01HD081216 · NICHD · UNIVERSITY OF TEXAS AT AUSTIN · PI FINNELL, RICHARD H., LEI, YUNPING · 2015 to 2019
$2.5M
Study of Neural Tube Defects Etiology: Genome and ExposomeR01ES021006 · NIEHS · UNIVERSITY OF TEXAS AT AUSTIN · PI FINNELL, RICHARD H., MASON, CHRISTOPHER EDWARD · 2012 to 2014
$1.0M
NICHD NIH HHS P01 HD067244NICHD NIH HHS R01 HD081216NICHD NIH HHS R01 HD083809NIEHS NIH HHS R01 ES021006NINDS NIH HHS R01 NS076465
6 · The paper itself

Abstract

Periconception maternal folic acid (vitamin B

Indexed as

AnimalsCiliaDactinomycinEmbryo, MammalianEmbryonic DevelopmentEmbryo, NonmammalianFolic AcidGene Expression Regulation, DevelopmentalHedgehog ProteinsHEK293 CellsHumansMethylationMiceNeural TubeNeural Tube DefectsPlasmidsDactinomycinFolic AcidHedgehog Proteinsmethylated actinomycin DSeptinsepigeneticsfolate transportneural tube defectseptin2

Identifiers

PMID28432198
PMCPMC5503710
OpenAlexW2606189516

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.