Evidence map›Paper›PMID 28432120›Full record

ArticleThe Journal of biological chemistry2017

Two glycosaminoglycan-binding domains of the mouse cytomegalovirus-encoded chemokine MCK-2 are critical for oligomerization of the full-length protein.

Sergio M Pontejo, Philip M Murphy

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Coreceptor functions of cell surface heparan sulfate proteoglycans.American journal of physiology. Cell physiology · 2022
    Review
  3. Article
  4. Article
  5. Article
  6. Chemokines encoded by herpesviruses.Journal of leukocyte biology · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Sergio M PontejoFrom the Laboratory of Molecular Immunology, NIAID, National Institutes of Health, Bethesda, Maryland 20892.
Philip M MurphyFrom the Laboratory of Molecular Immunology, NIAID, National Institutes of Health, Bethesda, Maryland 20892 pmm@nih.gov.
National Institutes of Health · US

Funding

Molecular Analysis Of Leukocyte Activation By ChemoattractantsZIAAI000615 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI MURPHY, PHILIP · 2009 to 2025
$44.8M
6 · The paper itself

Abstract

Chemokines are essential for antimicrobial host defenses and tissue repair. Herpesviruses and poxviruses also encode chemokines, copied from their hosts and repurposed for multiple functions, including immune evasion. The CC chemokine MCK-2 encoded by mouse CMV (MCMV) has an atypical structure consisting of a classic chemokine domain N-terminal to a second unique domain, resulting from the splicing of MCMV ORFs

Indexed as

AnimalsChemokines, CCGlycosaminoglycansHEK293 CellsHumansMiceMuromegalovirusNIH 3T3 CellsOpen Reading FramesProtein DomainsProtein MultimerizationProtein Structure, SecondaryViral ProteinsChemokines, CCGlycosaminoglycansMCK-2 protein, Mouse cytomegalovirus 1Viral Proteinschemokinecytomegalovirusglycosaminoglycanheparin-binding proteinoligomerizationviral protein

Identifiers

PMID28432120
PMCPMC5465486
OpenAlexW2607335644

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.