ReviewCold Spring Harbor perspectives in medicine2018
Effects of Exercise and Aging on Skeletal Muscle.
Review in Cold Spring Harbor perspectives in medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 260 papers, 15 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
260 citing papers in PubMed, 15 syntheses or guidelines pooled it, 459 citations in OpenAlex.
- The intervention effects of resistance exercise on sarcopenia in older adults: a systematic review and meta-analysis.BMC geriatrics · 2026Pooled it
- Exercise and nutritional interventions for sarcopenia-related fall prevention in older adults: An umbrella review.The journal of nutrition, health & aging · 2026Pooled it
- Mapping the effects of exercise on cognition and physical function: a scoping review of rodent studies.Frontiers in physiology · 2026Pooled it
- Sarcopenic Obesity and Cardiovascular Disease Risk and Mortality: A Systematic Review and Meta-Analysis.Anatolian journal of cardiology · 2025Pooled it
- Effects of ketogenic diet on muscle mass, strength, aerobic metabolic capacity, and endurance in adults: a systematic review and meta-analysis.Journal of health, population, and nutrition · 2025Pooled it
- The Effects of Glucagon-Like Peptide-1 Receptor Agonists on Mitochondrial Function Within Skeletal Muscle: A Systematic Review.Journal of cachexia, sarcopenia and muscle · 2025Pooled it
- Effects of Nicotinamide Mononucleotide Supplementation on Muscle and Liver Functions Among the Middle-aged and Elderly: A Systematic Review and Meta-analysis of Randomized Controlled Trials.Current pharmaceutical biotechnology · 2025Pooled it
- Effect of Bimagrumab on body composition: a systematic review and meta-analysis.Aging clinical and experimental research · 2024Pooled it
- Non invasive techniques for direct muscle quality assessment after exercise intervention in older adults: a systematic review.BMC geriatrics · 2024Pooled it
- Effect of non-pharmacological interventions on the prevention of sarcopenia in menopausal women: a systematic review and meta-analysis of randomized controlled trials.BMC women's health · 2023Pooled it
- The Effect of Long ChainNutrients · 2023Pooled it
- Association of muscle wasting with mortality risk among adults: A systematic review and meta-analysis of prospective studies.Journal of cachexia, sarcopenia and muscle · 2023Pooled it
- Are Morphometric Alterations of the Deep Neck Muscles Related to Primary Headache Disorders? A Systematic Review.Sensors (Basel, Switzerland) · 2023Pooled it
- Is functional training an efficient approach to improve body composition in older people? A systematic review.Frontiers in physiology · 2023Pooled it
- Systematic Review of the Effects of Exercise and Physical Activity on the Gut Microbiome of Older Adults.Nutrients · 2022Pooled it
- Effects of 12-week exercise on Meteorin-like levels, inflammation, and functional capacity in older adults: Korean national aging project randomized controlled study.European geriatric medicine · 2025Trial
- No evidence of pitavastatin effect on muscle area or density among people with HIV.AIDS (London, England) · 2025 · on this mapTrial
- ZiclagueOrphanet journal of rare diseases · 2025Trial
- Myokine Circulating Levels in Postmenopausal Women with Overweight or Obesity: Effects of Resistance Training and/or DHA-RichNutrients · 2025Trial
- A graded personalized exercise program's effect on muscle and body fat: randomized controlled trial.BMC public health · 2025Trial
200 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A substantial loss of muscle mass and strength (sarcopenia), a decreased regenerative capacity, and a compromised physical performance are hallmarks of aging skeletal muscle. These changes are typically accompanied by impaired muscle metabolism, including mitochondrial dysfunction and insulin resistance. A challenge in the field of muscle aging is to dissociate the effects of chronological aging per se on muscle characteristics from the secondary influence of lifestyle and disease processes. Remarkably, physical activity and exercise are well-established countermeasures against muscle aging, and have been shown to attenuate age-related decreases in muscle mass, strength, and regenerative capacity, and slow or prevent impairments in muscle metabolism. We posit that exercise and physical activity can influence many of the changes in muscle during aging, and thus should be emphasized as part of a lifestyle essential to healthy aging.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.