ArticleThe Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation2017
Ventricular assist device elicits serum natural IgG that correlates with the development of primary graft dysfunction following heart transplantation.
Article in The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Interplay of Pulmonary Hypertension and the Effects of Panel-Reactive Antibodies on Outcomes of Heart Transplant Recipients Bridged With Left Ventricular Assist Device.Journal of the American Heart Association · 2026Article
- Dominant intragraft plasma cells targeting bilirubin implicate local heme catabolism in human cardiac allograft vasculopathy.The Journal of clinical investigation · 2026Article
- Risk Estimation of Severe Primary Graft Dysfunction in Heart Transplant Recipients Using a Smartphone.Reviews in cardiovascular medicine · 2025Article
- The Interaction of Amiodarone and Continuous-flow Left Ventricular Assist Device Use in Risk of Severe Primary Graft Dysfunction Following Heart Transplantation.Transplantation direct · 2022Article
- Vascular rejection in cardiac allograft vasculopathy: Impact on graft survival.Frontiers in cardiovascular medicine · 2022Article
- Financial implications of using extracorporeal membrane oxygenation following heart transplantation.Interactive cardiovascular and thoracic surgery · 2021Article
- Current Desensitization Strategies in Heart Transplantation.Frontiers in immunology · 2021Review
- Intraoperative hemoglobin level and primary graft dysfunction in adult heart transplantation.General thoracic and cardiovascular surgery · 2020Article
- Profiling non-HLA antibody responses in antibody-mediated rejection following heart transplantation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2020Article
- Is There a Role for Natural Antibodies in Rejection Following Transplantation?Transplantation · 2019Review
- Impact of pretransplant antibodies on outcomes after heart transplantation.Current opinion in organ transplantation · 2019Review
- Early Acute Microvascular Kidney Transplant Rejection in the Absence of Anti-HLA Antibodies Is Associated with Preformed IgG Antibodies against Diverse Glomerular Endothelial Cell Antigens.Journal of the American Society of Nephrology : JASN · 2019Article
- Combined Heart and Kidney Transplantation: Clinical Experience in 100 Consecutive Patients.Journal of the American Heart Association · 2019Article
- Do natural antibodies have a detrimental effect after kidney transplantation?Annals of translational medicine · 2018Article
- Post-Transplant Natural Antibodies Associate with Kidney Allograft Injury and Reduced Long-Term Survival.Journal of the American Society of Nephrology : JASN · 2018Article
- New insights on innate B-cell immunity in transplantation.Xenotransplantation · 2018Review
- Complete B Cell Deficiency Reduces Allograft Inflammation and Intragraft Macrophages in a Rat Kidney Transplant Model.Transplantation · 2018Article
- Prevalence of polyreactive innate clones among graft--infiltrating B cells in human cardiac allograft vasculopathy.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2018Article
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18 authors.
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Abstract
backgroundPre-transplant sensitization is a limiting factor in solid-organ transplantation. In heart transplants, ventricular assist device (VAD) implantation has been associated with sensitization to human leukocyte antigens (HLA). The effect of VAD on non-HLA antibodies is unclear. We have previously shown that polyreactive natural antibodies (Nabs) contribute to pre-sensitization in kidney allograft recipients. Here we assessed generation of Nabs after VAD implantation in pre-transplant sera and examined their contribution to cardiac allograft outcome.
methodsIgM and IgG Nabs were tested in pre-transplant serum samples collected from 206 orthotopic heart transplant recipients, including 128 patients with VAD (VAD patients) and 78 patients without VAD (no-VAD patients). Nabs were assessed by testing serum reactivity to apoptotic cells by flow cytometry and to the generic oxidized epitope, malondialdehyde, by enzyme-linked immunosorbent assay.
resultsNo difference was observed in serum levels of IgM Nabs between VAD and no-VAD patients. However, serum IgG Nabs levels were significantly increased in VAD compared with no-VAD patients. This increase was likely due to the presence of the VAD, as revealed by lower serum IgG Nabs levels before implantation. Elevated pre-transplant IgG Nabs level was associated with development of primary graft dysfunction (PGD).
conclusionsOur study demonstrates that VAD support elicits IgG Nabs reactive to apoptotic cells and oxidized epitopes. These findings further support broad and non-specific B-cell activation by VAD, resulting in IgG sensitization. Moreover, the association of serum IgG Nabs levels with development of PGD suggests a possible role for these antibodies in the inflammatory reaction accompanying this complication.
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