ReviewNeuropharmacology2017
Influence of stress associated with chronic alcohol exposure on drinking.
Review in Neuropharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
107 citing papers in PubMed, 4 syntheses or guidelines pooled it, 187 citations in OpenAlex.
- Stress and alcohol impact network states involved in emotional processing: relevance of comorbid AUD and psychiatric illnesses.Psychopharmacology · 2026Pooled it
- Epidemiological characteristics of alcohol-related liver disease in China: a systematic review and meta-analysis.BMC public health · 2023Pooled it
- Meta-analysis of grey matter changes and their behavioral characterization in patients with alcohol use disorder.Scientific reports · 2021Pooled it
- Efficacy of probiotics on stress in healthy volunteers: A systematic review and meta-analysis based on randomized controlled trials.Brain and behavior · 2020Pooled it
- Alcohol withdrawal symptoms predict corticostriatal dysfunction that is reversed by prazosin treatment in alcohol use disorder.Addiction biology · 2022Trial
- Effect of interventions for stress management on blood pressure changes in healthy adults: a systematic review and meta-analysis.Journal of human hypertension · 2026Review
- Targeting PAI-1 with TM5441 Mitigates Chronic Social Stress-Induced Anxiety-Like Behavior and Stress-Induced Increases in Ethanol Intake and Preference.Neurochemical research · 2026Article
- Article
- Calcitonin Gene-Related Peptide Signalling in Alcohol Use Disorders: A Scoping Review.Drug and alcohol review · 2026Article
- Effects of Cannabidiol on Behavior and Oxidative Stress in a Rat Model of Depression Under Chronic Stress.Journal of xenobiotics · 2026Article
- Expression and Clinical Significance of the Long Non-Coding RNA OIP5-AS1 in Alcohol Use Disorder.Addiction biology · 2026Article
- Salivary Testosterone Concentration and Cognitive Impairment among Japanese Older Adults in the Toon Health Study.Neuroepidemiology · 2026Article
- G9a inhibition reduces stress-potentiated alcohol drinking in both male and female mice: Implications for safe and effective pharmacological therapeutics for alcohol use disorder.Alcohol, clinical & experimental research · 2026Article
- Psychological Distress, Resilience, and Immunoinflammatory Signatures in Healthcare Workers During COVID-19.Stress and health : journal of the International Society for the Investigation of Stress · 2026Article
- Transcription factors implicated in substance use disorder, from immediate early genes to altered gene expression.Brain research · 2026Review
- The persistent effects of exposure to a predator odor stressor on sensitivity to alcohol.Addiction neuroscience · 2025Article
- Adaptive Serum Biochemistry Responses to Ethanol Administration in a Mouse Model: Implications for Metabolic Regulation Under Analgesia.Molecules (Basel, Switzerland) · 2025Article
- Integrated single-cell multiomic profiling of caudate nucleus suggests key mechanisms in alcohol use disorder.Nature communications · 2025Article
- Work- and family-related stressors and risk of hazardous alcohol use: the role of social support. A cohort study in Sweden.Alcohol and alcoholism (Oxford, Oxfordshire) · 2025Article
- Article
47 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Stress is commonly regarded as an important trigger for relapse and a significant factor that promotes increased motivation to drink in some individuals. However, the relationship between stress and alcohol is complex, likely changing in form during the transition from early moderated alcohol use to more heavy uncontrolled alcohol intake. A growing body of evidence indicates that prolonged excessive alcohol consumption serves as a potent stressor, producing persistent dysregulation of brain reward and stress systems beyond normal homeostatic limits. This progressive dysfunctional (allostatic) state is characterized by changes in neuroendocrine and brain stress pathways that underlie expression of withdrawal symptoms that reflect a negative affective state (dysphoria, anxiety), as well as increased motivation to self-administer alcohol. This review highlights literature supportive of this theoretical framework for alcohol addiction. In particular, evidence for stress-related neural, physiological, and behavioral changes associated with chronic alcohol exposure and withdrawal experience is presented. Additionally, this review focuses on the effects of chronic alcohol-induced changes in several pro-stress neuropeptides (corticotropin-releasing factor, dynorphin) and anti-stress neuropeptide systems (nocicepton, neuropeptide Y, oxytocin) in contributing to the stress, negative emotional, and motivational consequences of chronic alcohol exposure. Studies involving use of animal models have significantly increased our understanding of the dynamic stress-related physiological mechanisms and psychological underpinnings of alcohol addiction. This, in turn, is crucial for developing new and more effective therapeutics for treating excessive, harmful drinking, particularly stress-enhanced alcohol consumption. This article is part of the Special Issue entitled "Alcoholism".
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.