Evidence map›Paper›PMID 28431811›Full record

ArticleAmerican journal of preventive medicine2017

Potential Consequences of Not Using Live Attenuated Influenza Vaccine.

Kenneth J Smith, Mary Patricia Nowalk, Angela Wateska, Shawn T Brown, Jay V DePasse, Jonathan M Raviotta, Eunha Shim, Richard K Zimmerman

Abstract read
In one paragraph

Article in American journal of preventive medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kenneth J SmithDepartment of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania. Electronic address: smithkj2@upmc.edu.
Mary Patricia NowalkDepartment of Family Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Angela WateskaDepartment of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Shawn T BrownPittsburgh Supercomputing Center, Carnegie Mellon University, Pittsburgh, Pennsylvania.
Jay V DePassePittsburgh Supercomputing Center, Carnegie Mellon University, Pittsburgh, Pennsylvania.
Jonathan M RaviottaDepartment of Family Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Eunha ShimDepartment of Mathematics, Soongsil University, Seoul, Republic of Korea.
Richard K ZimmermanDepartment of Family Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

Funding

Future of influenza vaccine strategies given interference and choiceR01GM111121 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SMITH, KENNETH J, ZIMMERMAN, RICHARD K · 2014 to 2017
$1.6M
NIGMS NIH HHS R01 GM111121
6 · The paper itself

Abstract

introductionDecreased live attenuated influenza vaccine (LAIV) effectiveness in the U.S. prompted the Advisory Committee on Immunization Practices in August 2016 to recommend against this vaccine's use. However, overall influenza uptake increases when LAIV is available and, unlike the U.S., LAIV has retained its effectiveness in other countries. These opposing countercurrents create a dilemma.

methodsTo examine the potential consequences of the decision to not recommend LAIV, which may result in decreased influenza vaccination coverage in the U.S. population, a Markov decision analysis model was used to examine influenza vaccination options in U.S. children aged 2-8 years. Data were compiled and analyzed in 2016.

resultsUsing recently observed low LAIV effectiveness values, fewer influenza cases will occur if LAIV is not used compared with having LAIV as a vaccine option. However, having the option to use LAIV may be favored if LAIV effectiveness returns to prior levels or if the absence of vaccine choice substantially decreases overall vaccine uptake.

conclusionsContinued surveillance of LAIV effectiveness and influenza vaccine uptake is warranted, given their importance in influenza vaccination policy decisions.

Indexed as

Models, TheoreticalChildChild, PreschoolHumansInfluenza, HumanInfluenza VaccinesNasal SpraysVaccinationInfluenza VaccinesNasal Sprays

Identifiers

PMID28431811
PMCPMC5610050

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.