ArticleBMC pharmacology & toxicology2017
Dichloroacetic acid-induced testicular toxicity in male rats and the protective effect of date fruit extract.
Article in BMC pharmacology & toxicology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 22 citations in OpenAlex.
- Histopathological examination and transcriptomic profiling reveal gossypol toxicity-responsive genes related to fertility in mice.Frontiers in pharmacology · 2025Article
- Novel microwave assisted carboxymethyl-graphene oxide and its hepatoprotective activity.BMC pharmacology & toxicology · 2024Article
- Urinary haloacetic acid concentrations in relation to sex and thyroid hormones among reproductive-aged men.Environment international · 2024Article
- Phytomedicinal therapeutics for male infertility: critical insights and scientific updates.Journal of natural medicines · 2022Review
- Salivary Lead Levels among Workers in Different Industrial Areas in the West Bank of Palestine: a Cross-Sectional Study.Biological trace element research · 2021Article
- Dichloroacetic acid-induced dysfunction in rat hippocampus and the protective effect of curcumin.Metabolic brain disease · 2021Article
- Fetal exposure to dichloroacetic acid and impaired cognitive function in the adulthood.Brain and behavior · 2020Article
- The prophylactic effect of date palm (International journal of reproductive biomedicine · 2020Article
- The Great Healing Potential Hidden in Plant Preparations of Antioxidant Properties: A Return to Nature?Oxidative medicine and cellular longevity · 2020Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe present study was designed to investigate the protective effect of aqueous date extract (ADE) against the dichloroacetic acid (DCA)-induced testicular injury in rats.
methodsForty-eight male Wistar rats were randomly divided into six groups of eight: group I served as the control; group II was given ADE (4 ml/kg) by gavage; groups III and IV received DCA at 0.5 and 2 g/L drinking water, respectively; and groups V and VI received DCA at 0.5 and 2 g/L drinking water, respectively, before ADE administration. The experiment was performed for two months.
resultsResults showed that the absolute weights of testes and epididymis were decreased following the DCA administration. The testosterone, FSH and LH levels were also decreased. Severe histopathological changes in testes were observed including degeneration of seminiferous tubules and depletion of germ cells. These changes were associated with alterations of oxidative stress markers. Levels of lipid peroxidation and SOD and CAT activities were increased, while activity of GPx and GSH levels were decreased. Pretreatment with ADE has effectively alleviated the oxidative stress induced by DCA thereby restoring these parameters to normal values.
conclusionsThese results suggest that ADE has a protective effect over DCA-induced oxidative damage in rat testes.
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