Evidence map›Paper›PMID 28431555›Full record

ArticleParticle and fibre toxicology2017

Reduction of pulmonary toxicity of metal oxide nanoparticles by phosphonate-based surface passivation.

Xiaoming Cai, Anson Lee, Zhaoxia Ji, Cynthia Huang, Chong Hyun Chang, Xiang Wang, Yu-Pei Liao, Tian Xia, Ruibin Li

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Particle and fibre toxicology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 78 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Toxicologic Concerns with Current Medical Nanoparticles.International journal of molecular sciences · 2022
    Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Review
  14. Article
  15. Nanotoxicity: a challenge for future medicineTurkish journal of medical sciences · 2020
    Review
  16. Article
  17. Article
  18. Review
  19. Current approaches for safer design of engineered nanomaterials.Ecotoxicology and environmental safety · 2018
    Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Xiaoming CaiCenter for Genetic Epidemiology and Genomics, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, 215123, China.
Anson LeeDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, California, 90095, USA.
Zhaoxia JiCalifornia NanoSystems Institute, University of California, Los Angeles, California, 90095, USA.
Cynthia HuangDepartment of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, California, 90095, USA.
Chong Hyun ChangCalifornia NanoSystems Institute, University of California, Los Angeles, California, 90095, USA.
Xiang WangCalifornia NanoSystems Institute, University of California, Los Angeles, California, 90095, USA.
Yu-Pei LiaoDepartment of Medicine, University of California, Los Angeles, California, 90095, USA.
Tian XiaDepartment of Medicine, University of California, Los Angeles, California, 90095, USA. txia@ucla.edu.
Ruibin LiSchool for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou, 215123, China. liruibin@suda.edu.cn.ORCID 0000-0001-6471-7658
California NanoSystems Institute · USUniversity of California, Los Angeles · USSoochow University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe wide application of engineered nanoparticles has induced increasing exposure to humans and environment, which led to substantial concerns on their biosafety. Some metal oxides (MOx) have shown severe toxicity in cells and animals, thus safe designs of MOx with reduced hazard potential are desired. Currently, there is a lack of a simple yet effective safe design approach for the toxic MOx. In this study, we determined the key physicochemical properties of MOx that lead to cytotoxicity and explored a safe design approach for toxic MOx by modifying their hazard properties.

resultsTHP-1 and BEAS-2B cells were exposed to 0-200 μg/mL MOx for 24 h, we found some toxic MOx including CoO, CuO, Ni

conclusionsThe surface reactivity of MOx including ion shedding and oxidative potential is the dominated physicochemical property that is responsible for the cytotoxicity induced by MOx. EDTMP coating could passivate the surface of MOx, reduce their cytotoxicity and pulmonary hazard effects. This coating would be an effective safe design approach for a broad spectrum of toxic MOx, which will facilitate the safe use of MOx in commercial nanoproducts.

Indexed as

AnimalsBronchoalveolar Lavage FluidCell LineCell SurvivalCoated Materials, BiocompatibleHumansInhalation ExposureLungMaleMetal NanoparticlesMetals, HeavyMice, Inbred C57BLOrganophosphonatesOxidative StressOxidesParticle SizeCoated Materials, BiocompatibleMetals, HeavyOrganophosphonatesOxidesReactive Oxygen SpeciesFunctionalizationInflammationInhalationLung toxicityMetal oxidesNanotoxicitySurface coating

Identifiers

PMID28431555
PMCPMC5399805
OpenAlexW2606193202

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.