ArticleOncotarget2017
Association of the VDAC3 gene polymorphism with sperm count in Han-Chinese population with idiopathic male infertility.
Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- Survivin Associates with VDAC2 and Bcl2-Family Proteins at the Mitochondrial Outer Membrane.International journal of molecular sciences · 2026Article
- The systems that transport ions and their impact on sperm function and male fertility.Function (Oxford, England) · 2026Review
- Exploring Single-Nucleotide Polymorphisms in Primary and Secondary Male Infertility.Medical sciences (Basel, Switzerland) · 2025Article
- Aromatase reduces sperm motility by down-regulating the expression of proteins related to ATP synthesis in seminal plasma extracellular vesicles.BMC genomics · 2025Article
- Voltage-Dependent Anion Channels in Male Reproductive Cells: Players in Healthy Fertility?Biomolecules · 2024Review
- Single-cell-resolution transcriptome map revealed novel genes involved in testicular germ cell progression and somatic cells specification in Chinese tongue sole with sex reversal.Science China. Life sciences · 2023Article
- Renaissance of VDAC: New Insights on a Protein Family at the Interface between Mitochondria and Cytosol.Biomolecules · 2021Review
- Voltage-Dependent Anion Selective Channel 3: Unraveling Structural and Functional Features of the Least Known Porin Isoform.Frontiers in physiology · 2021Review
- Is the secret of VDAC Isoforms in their gene regulation? Characterization of humanInternational journal of molecular sciences · 2020Article
- Genome-wide association study of semen volume, sperm concentration, testis size, and plasma inhibin B levels.Journal of human genetics · 2020Article
- CDK2 regulates the NRF1/The Journal of cell biology · 2019Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Voltage-dependent anion channel (VDAC) is a multifunctional channel protein across the outer mitochondrial membrane of somatic cells and participates in many physiological and pathophysiological processes. Up to now, only a few studies, including our previous studies, showed that VDAC exists in mammalian spermatozoa and is involved in spermatogenesis and sperm functions. There is no report about VDAC genetic variants in germinal tissues or cells. To investigate the possible association between VDAC genetic variants and human sperm quality, we performed semen analysis and variant Genotyping of VDAC3 subtype (rs7004637, rs16891278 and rs6773) of 523 Han-Chinese males with idiopathic infertility respectively by computer assisted semen analysis (CASA) and single nucleotide polymorphism (SNP) Genotyping assay. No significant association was found between rs7004637 and rs6773 genotypes and semen quality. However, the AG genotype of rs16891278 showed a significantly lower sperm concentration compared with the AA genotype (P = 0.044). Our findings suggest that VDAC3 genetic variants may be associated with human sperm count.
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