ArticleThe Journal of nutritional biochemistry2017
Trehalose supplementation reduces hepatic endoplasmic reticulum stress and inflammatory signaling in old mice.
Article in The Journal of nutritional biochemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 56 citations in OpenAlex.
- Chondroitin Sulfate Supplementation Is Associated with Body Weight Control in Ovariectomized Rats: A Multi-Omics Study of Gut Microbiota and Metabolite Profiles.Biomolecules · 2026Article
- Trehalose as an anti-inflammatory agent: insights into molecular mechanisms and therapeutic applications.Inflammopharmacology · 2026Review
- Integrative Analysis of the Microbiome and Metabolome of Broiler Intestine: Insights into the Mechanisms of Probiotic Action as an Antibiotic Substitute.Probiotics and antimicrobial proteins · 2025Article
- Trehalose Ameliorates Zebrafish Emotional and Social Deficits Caused by CLN8 Dysfunction.Cells · 2025Article
- Assessing the efficacy of the natural disaccharide trehalose in ameliorating diet-induced obesity and metabolic dysfunction.Frontiers in nutrition · 2025Article
- Trehalose-induced SIRT1/AMPK activation regulates SREBP-1c/PPAR-α to alleviate lipid accumulation in aged liver.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
- Trehalose Supplementation Effects on Growth, Intestinal Morphology, Gut Bacteria, and Footpad Dermatitis of Broiler Chickens Reared at High Density.The journal of poultry science · 2024Article
- A neuroprotective dose of trehalose is harmless to metabolic organs: comprehensive histopathological analysis of liver, pancreas, and kidney.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2023Article
- The tetraspanin transmembrane protein CD53 mediates dyslipidemia and integrates inflammatory and metabolic signaling in hepatocytes.The Journal of biological chemistry · 2023Article
- Trehalose Attenuates Learning and Memory Impairments in Aged Rats via Overexpression of miR-181c.Neurochemical research · 2022Article
- Trehalose Attenuates Oxidative Stress and Endoplasmic Reticulum Stress-Mediated Apoptosis in IPEC-J2 Cells Subjected to Heat Stress.Animals : an open access journal from MDPI · 2022Article
- Trehalose ameliorates prodromal non-motor deficits and aberrant protein accumulation in a rotenone-induced mouse model of Parkinson's disease.Archives of pharmacal research · 2022Article
- Effects of trehalose on NFE2L2, catalase, and superoxide dismutase in the kidney of aged rats.Molecular biology research communications · 2022Article
- Lifespan prolonging mechanisms and insulin upregulation without fat accumulation in long-lived reproductives of a higher termite.Communications biology · 2022Article
- Understanding the Unique Microenvironment in the Aging Liver.Frontiers in medicine · 2022Review
- Hepatoprotective Effect of Trehalose: Insight into Its Mechanisms of Action.Advances in experimental medicine and biology · 2021Article
- Effect of trehalose supplementation on growth performance and intestinal morphology in broiler chickens.Veterinary and animal science · 2020Article
- Microbial and metabolic impacts of trehalose and trehalose analogues.Gut microbes · 2020Article
- Using trehalose to prevent and treat metabolic function: effectiveness and mechanisms.Current opinion in clinical nutrition and metabolic care · 2019Review
- The Influence of Trehalose on Atherosclerosis and Hepatic Steatosis in Apolipoprotein E Knockout Mice.International journal of molecular sciences · 2019Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
The accumulation of damaged proteins can perturb cellular homeostasis and provoke aging and cellular damage. Quality control systems, such as the unfolded protein response (UPR), inflammatory signaling and protein degradation, mitigate the residence time of damaged proteins. In the present study, we have examined the UPR and inflammatory signaling in the liver of young (~6 months) and old (~28 months) mice (n=8/group), and the ability of trehalose, a compound linked to increased protein stability and autophagy, to counteract age-induced effects on these systems. When used, trehalose was provided for 4 weeks in the drinking water immediately prior to sacrifice (n=7/group). Livers from old mice were characterized by activation of the UPR, increased inflammatory signaling and indices of liver injury. Trehalose treatment reduced the activation of the UPR and inflammatory signaling, and reduced liver injury. Reductions in proteins involved in autophagy and proteasome activity observed in old mice were restored following trehalose treatment. The autophagy marker, LC3B-II, was increased in old mice treated with trehalose. Metabolomics analyses demonstrated that reductions in hexosamine biosynthetic pathway metabolites and nicotinamide in old mice were restored following trehalose treatment. Trehalose appears to be an effective intervention to reduce age-associated liver injury and mitigate the need for activation of quality control systems that respond to disruption of proteostasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.