Evidence map›Paper›PMID 28431262›Full record

ReviewCancer treatment reviews2017

Immunologic approaches for the treatment of multiple myeloma.

Leo Rasche, Niels Weinhold, Gareth J Morgan, Frits van Rhee, Faith E Davies

Abstract readReview
In one paragraph

Review in Cancer treatment reviews, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Recent advances in targeted drug delivery systems for multiple myeloma.Journal of controlled release : official journal of the Controlled Release Society · 2024
    Review
  4. Article
  5. Review
  6. BCMA in Multiple Myeloma-A Promising Key to Therapy.Journal of clinical medicine · 2021
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Review
  15. Article
  16. Immunotherapy in myeloma: how far have we come?Therapeutic advances in hematology · 2019
    Review
  17. CARs and other T cell therapies for MM: The clinical experience.Best practice & research. Clinical haematology · 2018
    Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Leo RascheMyeloma Institute, University of Arkansas for Medical Sciences, Little Rock, AR, USA. Electronic address: LRasche@uams.edu.
Niels WeinholdMyeloma Institute, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Gareth J MorganMyeloma Institute, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Frits van RheeMyeloma Institute, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Faith E DaviesMyeloma Institute, University of Arkansas for Medical Sciences, Little Rock, AR, USA.

Funding

Tumor Cell-Microenvironment Interactions in the Molecular Pathogenesis of MultiplP01CA055819 · NCI · UNIV OF ARKANSAS FOR MED SCIS · PI BELLAMY, WILLIAM T · 1993 to 2013
$49.7M
NCI NIH HHS P01 CA055819
6 · The paper itself

Abstract

The FDA approval of two monoclonal antibodies in 2015has heralded a new era of targeted immunotherapies for multiple myeloma (MM). In this review we discuss the recent approaches using different immunological components to treat MM. In particular, we review current monoclonal antibody based therapies, engineered T- and NK cell products, 'off-target' immunomodulation, and strategies utilizing allogeneic cell transplantation in MM. We discuss how an immunologic approach offers promise for the treatment of this genetically heterogeneous disease, and how patients with acquired drug resistance may particularly benefit from these therapies. We also describe some of the limitations of the current strategies and speculate on the future of personalized immunotherapies for MM.

Indexed as

ImmunotherapyT-LymphocytesADP-ribosyl Cyclase 1Antibodies, MonoclonalAntibodies, Monoclonal, HumanizedHumansLymphocyte ActivationLymphocytes, Tumor-InfiltratingMultiple MyelomaStem Cell TransplantationTransplantation, HomologousADP-ribosyl Cyclase 1Antibodies, MonoclonalAntibodies, Monoclonal, HumanizeddaratumumabelotuzumabAllogeneic stem cell transplantationCheckpoint inhibitorsChimeric antigen receptor (CAR) T cellsImmunotherapyMonoclonal antibodiesMultiple myeloma

Identifiers

PMID28431262
PMCPMC5604432

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.