Evidence map›Paper›PMID 28431181›Full record

ArticleNeurosurgery2017

Protective Effect of Mesenchymal Stem Cells Against the Development of Intracranial Aneurysm Rupture in Mice.

Atsushi Kuwabara, Jia Liu, Yoshinobu Kamio, Airan Liu, Michael T Lawton, Jae-Woo Lee, Tomoki Hashimoto

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurosurgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Atsushi KuwabaraDepartments of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, California.
Jia LiuDepartments of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, California.
Yoshinobu KamioDepartments of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, California.
Airan LiuDepartments of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, California.
Michael T LawtonDepartments of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, California.
Jae-Woo LeeDepartments of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, California.
Tomoki HashimotoDepartments of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, California.
University of California, San Francisco · US

Funding

Human Mesenchymal Stem Cell Microvesicles for the Treatment of Acute Lung InjuryR01HL113022 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LEE, JAE WOO · 2012 to 2020
$4.1M
The Role of Mast Cells in the Pathophysiology of Intracranial AneurysmR01NS082280 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HASHIMOTO, TOMOKI · 2013 to 2017
$1.7M
NHLBI NIH HHS R01 HL113022NINDS NIH HHS R01 NS082280
6 · The paper itself

Abstract

backgroundMesenchymal stem cells (MSCs) are multipotent stem or stromal cells found in multiple tissues. Intravenous MSC injections have been used to treat various diseases with an inflammatory component in animals and humans. Inflammation is emerging as a key component of pathophysiology of intracranial aneurysms. Modulation of inflammation by MSCs may affect sustained inflammatory processes that lead to aneurysmal rupture.

objectiveTo assess the effect of MSCs on the development of aneurysm rupture using a mouse model.

methodsIntracranial aneurysms were induced with a combination of a single elastase injection into the cerebrospinal fluid and deoxycorticosterone acetate salt-induced hypertension in mice. We administered allogeneic bone marrow-derived MSCs or vehicle, 6 and 9 d after aneurysm induction.

resultsMSC administration significantly reduced rupture rate (vehicle control vs MSCs, 90% vs 36%; P < .05). In cell culture experiments with an MSC and mast cell coculture, MSCs stabilized mast cells through cyclooxygenase-2 (COX-2)-dependent production of prostaglandin E2, thereby reducing the release of proinflammatory cytokines from mast cells. Pretreatment of MSCs with COX-2 inhibitor, NS-398, abolished the protective effect of MSCs against the development of aneurysm rupture.

conclusionIntravenous administration of MSCs after aneurysm formation prevented aneurysmal rupture in mice. The protective effect of MSCs against the development of aneurysm rupture appears to be mediated in part by the stabilization of mast cells by MSCs.

Indexed as

Mast CellsAneurysm, RupturedAnimalsHeterograftsHumansIntracranial AneurysmMaleMesenchymal Stem Cell TransplantationMiceMice, Inbred C57BLIntracranial aneurysmMesenchymal stem cellsStrokeSubarachnoid hemorrhage

Identifiers

PMID28431181
PMCPMC6257015
OpenAlexW2605909203

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.