ArticleSleep2017
Combining Human Epigenetics and Sleep Studies in Caenorhabditis elegans: A Cross-Species Approach for Finding Conserved Genes Regulating Sleep.
Article in Sleep, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Longitudinal associations of DNA methylation and sleep in children: a meta-analysis.Clinical epigenetics · 2022Pooled it
- Pooled it
- A genetically encoded sensor of ionic stress links cellular proton dynamics to sleep.Science advances · 2026Article
- A genetically encoded ionic-stress sensor reveals protons as a sleep driver.bioRxiv : the preprint server for biology · 2026Article
- Brain region and cell specificity ofWorld journal of psychiatry · 2025Article
- Article
- Pooled, Long-read Sequencing for Structural Variant Characterization in Schistosome Populations.Genome biology and evolution · 2025Article
- Cross-tissue transcriptome-wide association study reveals novel psoriasis susceptibility genes.Journal of translational autoimmunity · 2025Article
- Review
- Childhood adversity and adolescent epigenetic age acceleration: the role of adolescent sleep health.Sleep advances : a journal of the Sleep Research Society · 2025Article
- Childhood Adversity and Adolescent Epigenetic Age Acceleration: The Role of Adolescent Sleep Health.medRxiv : the preprint server for health sciences · 2024Article
- The Importance of Sleep in Overcoming Childhood Obesity and Reshaping Epigenetics.Biomedicines · 2024Review
- Sleep deficiency among people living with human immunodeficiency virus: A growing challenge.HIV medicine · 2024Review
- Objective and subjective measures of sleep initiation are differentially associated with DNA methylation in adolescents.Clinical epigenetics · 2023Article
- An Overview of Epigenetics in Obesity: The Role of Lifestyle and Therapeutic Interventions.International journal of molecular sciences · 2022Review
- Short Sleep Duration and Erectile Dysfunction: A Review of the Literature.Nature and science of sleep · 2022Review
- Genome-wide DNA methylation patterns associated with sleep and mental health in children: a population-based study.Journal of child psychology and psychiatry, and allied disciplines · 2020Article
- A pilot prospective study of sleep patterns and DNA methylation-characterized epigenetic aging in young adults.BMC research notes · 2019Article
- Sleep Deprivation and the Epigenome.Frontiers in neural circuits · 2018Review
- Worms sleep: a perspective.Journal of neurogeneticsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
Study Objectives: We aimed to test a combined approach to identify conserved genes regulating sleep and to explore the association between DNA methylation and sleep length. Methods: We identified candidate genes associated with shorter versus longer sleep duration in college students based on DNA methylation using Illumina Infinium HumanMethylation450 BeadChip arrays. Orthologous genes in Caenorhabditis elegans were identified, and we examined whether their loss of function affected C. elegans sleep. For genes whose perturbation affected C. elegans sleep, we subsequently undertook a small pilot study to re-examine DNA methylation in an independent set of human participants with shorter versus longer sleep durations. Results: Eighty-seven out of 485,577 CpG sites had significant differential methylation in young adults with shorter versus longer sleep duration, corresponding to 52 candidate genes. We identified 34 C. elegans orthologs, including NPY/flp-18 and flp-21, which are known to affect sleep. Loss of five additional genes alters developmentally timed C. elegans sleep (B4GALT6/bre-4, DOCK180/ced-5, GNB2L1/rack-1, PTPRN2/ida-1, ZFYVE28/lst-2). For one of these genes, ZFYVE28 (also known as hLst2), the pilot replication study again found decreased DNA methylation associated with shorter sleep duration at the same two CpG sites in the first intron of ZFYVE28. Conclusions: Using an approach that combines human epigenetics and C. elegans sleep studies, we identified five genes that play previously unidentified roles in C. elegans sleep. We suggest sleep duration in humans may be associated with differential DNA methylation at specific sites and that the conserved genes identified here likely play roles in C. elegans sleep and in other species.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.