Evidence map›Paper›PMID 28430976›Full record

Trial reportThe international journal of neuropsychopharmacology2017

Acute and Chronic Noradrenergic Effects on Cortical Excitability in Healthy Humans.

Hsiao-I Kuo, Walter Paulus, Giorgi Batsikadze, Asif Jamil, Min-Fang Kuo, Michael A Nitsche

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The international journal of neuropsychopharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 39 citations in OpenAlex.

  1. The neurobiological markers of acute alcohol's subjective effects in humans.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022
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  15. Noradrenergic Enhancement of Motor Learning, Attention, and Working Memory in Humans.The international journal of neuropsychopharmacology · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Hsiao-I KuoDepartment of Clinical Neurophysiology, University Medical Center, Georg-August-University, Göttingen, Germany (Ms H.-I. Kuo, Paulus, Mr Jamil, and Nitsche); Department of Psychology and Neurosciences, Leibniz Research Centre for Working Environment and Human Factors, Dortmund, Germany (Ms H.-I. Kuo, Mr Jamil, M.-F. Kuo, and Nitsche); Department of Neurology, University Medical Hospital Bergmannsheil, Bochum, Germany (Dr Nitsche); Department of Neurology, Essen University Hospital, University of Duisburg-Essen, Germany (Dr Batsikadze).
Walter PaulusDepartment of Clinical Neurophysiology, University Medical Center, Georg-August-University, Göttingen, Germany (Ms H.-I. Kuo, Paulus, Mr Jamil, and Nitsche); Department of Psychology and Neurosciences, Leibniz Research Centre for Working Environment and Human Factors, Dortmund, Germany (Ms H.-I. Kuo, Mr Jamil, M.-F. Kuo, and Nitsche); Department of Neurology, University Medical Hospital Bergmannsheil, Bochum, Germany (Dr Nitsche); Department of Neurology, Essen University Hospital, University of Duisburg-Essen, Germany (Dr Batsikadze).
Giorgi BatsikadzeDepartment of Clinical Neurophysiology, University Medical Center, Georg-August-University, Göttingen, Germany (Ms H.-I. Kuo, Paulus, Mr Jamil, and Nitsche); Department of Psychology and Neurosciences, Leibniz Research Centre for Working Environment and Human Factors, Dortmund, Germany (Ms H.-I. Kuo, Mr Jamil, M.-F. Kuo, and Nitsche); Department of Neurology, University Medical Hospital Bergmannsheil, Bochum, Germany (Dr Nitsche); Department of Neurology, Essen University Hospital, University of Duisburg-Essen, Germany (Dr Batsikadze).
Asif JamilDepartment of Clinical Neurophysiology, University Medical Center, Georg-August-University, Göttingen, Germany (Ms H.-I. Kuo, Paulus, Mr Jamil, and Nitsche); Department of Psychology and Neurosciences, Leibniz Research Centre for Working Environment and Human Factors, Dortmund, Germany (Ms H.-I. Kuo, Mr Jamil, M.-F. Kuo, and Nitsche); Department of Neurology, University Medical Hospital Bergmannsheil, Bochum, Germany (Dr Nitsche); Department of Neurology, Essen University Hospital, University of Duisburg-Essen, Germany (Dr Batsikadze).
Min-Fang KuoDepartment of Clinical Neurophysiology, University Medical Center, Georg-August-University, Göttingen, Germany (Ms H.-I. Kuo, Paulus, Mr Jamil, and Nitsche); Department of Psychology and Neurosciences, Leibniz Research Centre for Working Environment and Human Factors, Dortmund, Germany (Ms H.-I. Kuo, Mr Jamil, M.-F. Kuo, and Nitsche); Department of Neurology, University Medical Hospital Bergmannsheil, Bochum, Germany (Dr Nitsche); Department of Neurology, Essen University Hospital, University of Duisburg-Essen, Germany (Dr Batsikadze).
Michael A NitscheDepartment of Clinical Neurophysiology, University Medical Center, Georg-August-University, Göttingen, Germany (Ms H.-I. Kuo, Paulus, Mr Jamil, and Nitsche); Department of Psychology and Neurosciences, Leibniz Research Centre for Working Environment and Human Factors, Dortmund, Germany (Ms H.-I. Kuo, Mr Jamil, M.-F. Kuo, and Nitsche); Department of Neurology, University Medical Hospital Bergmannsheil, Bochum, Germany (Dr Nitsche); Department of Neurology, Essen University Hospital, University of Duisburg-Essen, Germany (Dr Batsikadze).
BG University Hospital Bergmannsheil Bochum · DEUniversity of Göttingen · DELeibniz Research Centre for Working Environment and Human Factors · DETU Dortmund University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Noradrenaline is a major neuromodulator in the central nervous system, and it is involved in the pathophysiology of diverse neuropsychiatric diseases. Previous transcranial magnetic stimulation studies suggested that acute application of selective noradrenaline reuptake inhibitors enhances cortical excitability in the human brain. However, other, such like clinical effects, usually require prolonged noradrenaline reuptake inhibitor treatment, which might go along with different physiological effects. Methods: The purpose of this study was to investigate the acute and chronic effects of the selective noradrenaline reuptake inhibitor reboxetine on cortical excitability in healthy humans in a double-blind, placebo-controlled, randomized crossover study. Sixteen subjects were assessed with different transcranial magnetic stimulation measurements: motor thresholds, input-output curve, short-latency intracortical inhibition and intracortical facilitation, I-wave facilitation, and short-interval afferent inhibition before and after placebo or reboxetine (8 mg) single-dose administration. Afterwards, the same subjects took reboxetine (8 mg/d) consecutively for 21 days. During this period (subjects underwent 2 experimental sessions with identical transcranial magnetic stimulation measures under placebo or reboxetine), transcranial magnetic stimulation measurements were assessed before and after drug intake. Results: Both single-dose and chronic administration of reboxetine increased cortical excitability; increased the slope of the input-output curve, intracortical facilitation, and I-wave facilitation; but decreased short-latency intracortical inhibition and short-interval afferent inhibition. Moreover, chronic reboxetine showed a larger enhancement of intracortical facilitation and I-wave facilitation compared with single-dose application. Conclusions: The results show physiological mechanisms of noradrenergic enhancement possibly underlying the functional effects of reboxetine regarding acute and chronic application.

Indexed as

AdolescentAdrenergic Uptake InhibitorsAdultAnalysis of VarianceCross-Over StudiesDouble-Blind MethodEvoked Potentials, MotorFemaleFollow-Up StudiesHandHumansMaleMiddle AgedMorpholinesMotor CortexMuscle, SkeletalAdrenergic Uptake InhibitorsMorpholinesReboxetinecortical excitabilitynoradrenalinereboxetinetranscranial magnetic stimulation

Identifiers

PMID28430976
PMCPMC5574667
OpenAlexW2605467721

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.