ArticleGenome biology and evolution2017
Evidence for a Strong Correlation Between Transcription Factor Protein Disorder and Organismic Complexity.
Article in Genome biology and evolution, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Current Challenges of Transcription Compartmentalization Research.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Inferring Gene Networks from High-Throughput Transcriptomes.Methods in molecular biology (Clifton, N.J.) · 2026Article
- The emerging roles of long non-coding RNAs in the nervous system.Nature reviews. Neuroscience · 2025Review
- Intrinsic Disorder and Phase Separation Coordinate Exocytosis, Motility, and Chromatin Remodeling in the Human Acrosomal Proteome.Proteomes · 2025Article
- Transcription factor prediction using protein 3D secondary structures.Bioinformatics (Oxford, England) · 2024Article
- Molecular Imaging of Fibroblast Activation in Rabbit Atherosclerotic Plaques: a Preclinical PET/CT Study.Molecular imaging and biology · 2024Article
- IndiSPENsable for X Chromosome Inactivation and Gene Silencing.Epigenomes · 2023Review
- Intrinsically disordered proteins and conformational noise: The hypothesis a decade later.iScience · 2023Review
- Gene loss during a transition to multicellularity.Scientific reports · 2023Article
- Enrichment of intrinsically disordered residues in ohnologs facilitates abiotic stress resilience in Brassica rapa.Journal of plant research · 2023Article
- Computational prediction of disordered binding regions.Computational and structural biotechnology journal · 2023Review
- HSF1, Aging, and Neurodegeneration.Advances in experimental medicine and biology · 2023Review
- Alternative splicing level related to intron size and organism complexity.BMC genomics · 2021Article
- Growth of Biological Complexity from Prokaryotes to Hominids Reflected in the Human Genome.International journal of molecular sciences · 2021Article
- On the roles of intrinsically disordered proteins and regions in cell communication and signaling.Cell communication and signaling : CCS · 2021Article
- Protein Aggregation Landscape in Neurodegenerative Diseases: Clinical Relevance and Future Applications.International journal of molecular sciences · 2021Review
- Harnessing the potential of plant transcription factors in developing climate resilient crops to improve global food security: Current and future perspectives.Saudi journal of biological sciences · 2021Review
- The Participation of the Intrinsically Disordered Regions of the bHLH-PAS Transcription Factors in Disease Development.International journal of molecular sciences · 2021Article
- Intrinsic disorder in protein domains contributes to both organism complexity and clade-specific functions.Scientific reports · 2021Article
- Towards an understanding of the role of intrinsic protein disorder on plant adaptation to environmental challenges.Cell stress & chaperones · 2021Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Studies of diverse phylogenetic lineages reveal that protein disorder increases in concert with organismic complexity but that differences nevertheless exist among lineages. To gain insight into this phenomenology, we analyzed all of the transcription factor (TF) families for which sequences are known for 17 species spanning bacteria, yeast, algae, land plants, and animals and for which the number of different cell types has been reported in the primary literature. Although the fraction of disordered residues in TF sequences is often moderately or poorly correlated with organismic complexity as gauged by cell-type number (r2 < 0.5), an unbiased and phylogenetically broad analysis shows that organismic complexity is positively and strongly correlated with the total number of TFs, the number of their spliced variants and their total disordered residues content (r2 > 0.8). Furthermore, the correlation between the fraction of disordered residues and cell-type number becomes stronger when confined to the TF families participating in cell cycle, cell size, cell division, cell differentiation, or cell proliferation, and other important developmental processes. The data also indicate that evolutionarily simpler organisms allow for the detection of subtle differences in the conserved IDRs of TFs as well as changes in variable IDRs, which can influence the DNA recognition and multifunctionality of TFs through direct or indirect mechanisms. Although strong correlations cannot be taken as evidence for cause-and-effect relationships, we interpret our data to indicate that increasing TF disorder likely was an important factor contributing to the evolution of organismic complexity and not merely a concurrent unrelated effect of increasing organismic complexity.
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