ArticleEuropean heart journal2017
Risk for hypertension crosses generations in the community: a multi-generational cohort study.
Article in European heart journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 83 citations in OpenAlex.
- Pulsatile Hemodynamics of Prehypertension and Hypertension: Associations with Pressure and Sex.Annals of biomedical engineering · 2026Article
- Combined AGT M235T-ACE I/D genotype and risk of essential hypertension in Vietnamese adults: a hospital-based case-control study.BMC cardiovascular disorders · 2026Article
- The association of early-onset diabetes mellitus with early-onset hypertension and premature all-cause mortality: a study based on NHANES.Diabetology & metabolic syndrome · 2026Article
- Early-onset hypertension associated with a CACNA1H variant of uncertain significance: a case report and literature review.BMC cardiovascular disorders · 2026Review
- Continuous assessment and research on enhanced blood pressure control - CareBP study.Frontiers in cardiovascular medicine · 2026Article
- Interaction between sleep disorder and depression on early onset hypertension: a machine learning modelling approach.Archives of public health = Archives belges de sante publique · 2025Article
- Associations of family history of hypertension, genetic, and lifestyle risks with incident hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Mineralocorticoid effects of fludrocortisone and hydrocortisone in primary adrenal insufficiency: EU-AIR patient data.Journal of endocrinological investigation · 2025Observational
- Screening hypertension using non-laboratory risk factors with machine learning: a retrospective cross-sectional study in Indonesia.BMJ open · 2025Article
- Associations of socioeconomic status and healthy lifestyle with incident early-onset and late-onset hypertension: a nationwide prospective cohort study in the UK.Population health metrics · 2025Article
- Genomic Exploration of Essential Hypertension in African-Brazilian Quilombo Populations: A Comprehensive Approach With Pedigree Analysis and Family-Based Association Studies.Journal of the American Heart Association · 2025Article
- Modifiable lifestyle factors in the primordial prevention of hypertension in three US cohorts.European journal of internal medicine · 2025Article
- Association between parental high-sensitive C-reactive protein and hypertension in offspring: an intergenerational study.Clinical hypertension · 2025Article
- Blood Pressure Trajectories During Young Adulthood and Cardiovascular Events in Later Life.American journal of hypertension · 2024Article
- Genetic and Epigenetic Mechanisms Regulating Blood Pressure and Kidney Dysfunction.Hypertension (Dallas, Tex. : 1979) · 2024Review
- Combined effect of time in target range and variability of systolic blood pressure on cardiovascular outcomes and mortality in patients with hypertension: A prospective cohort study.Journal of clinical hypertension (Greenwich, Conn.) · 2024Article
- Histone Modifications and Their Contributions to Hypertension.Hypertension (Dallas, Tex. : 1979) · 2024Review
- Grip strength positively correlates with blood pressure in individuals with abnormal adiposity.Journal of human hypertension · 2024Article
- Instrumental variable approach on analyzing risk factors associated with noncommunicable disease prevalence in Tanzania: A nonexperimental design.Health science reports · 2023Article
- Decoding the mechanism of hypertension through multiomics profiling.Journal of human hypertension · 2023Review
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
aimsParental hypertension is known to predict high blood pressure (BP) in children. However, the extent to which risk for hypertension is conferred across multiple generations, notwithstanding the impact of environmental factors, is unclear. Our objective was therefore to evaluate the degree to which risk for hypertension extends across multiple generations of individuals in the community. METHODS AND
resultsWe studied three generations of Framingham Heart Study participants with standardized blood pressure measurements performed at serial examinations spanning 5 decades (1948 through 2005): First Generation (n = 1809), Second Generation (n = 2631), and Third Generation (n = 3608, mean age 39 years, 53% women). To capture a more precise estimate of conferrable risk, we defined early-onset hypertension (age <55 years) as the primary exposure. In multinomial logistic regression models adjusting for standard risk factors as well as physical activity and daily intake of dietary sodium, risk for hypertension in the Third Generation was conferred simultaneously by presence of early-onset hypertension in parents [OR 2.10 (95% CI, 1.66-2.67), P < 0.001] as well as in grandparents [OR 1.33 (95% CI, 1.12-1.58), P < 0.01].
conclusionEarly-onset hypertension in grandparents raises the risk for hypertension in grandchildren, even after adjusting for early-onset hypertension in parents and lifestyle factors. These results suggest that a substantial familial predisposition for hypertension exists, and this predisposition is not identical when assessed from one generation to the next. Additional studies are needed to elucidate the mechanisms underlying transgenerational risk for hypertension and its clinical implications.
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