ArticleBioinformatics (Oxford, England)2017
Mapping genes for calcium signaling and their associated human genetic disorders.
Article in Bioinformatics (Oxford, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 29 citations in OpenAlex.
- The CaThe Journal of biological chemistry · 2026Article
- Mapping the transcriptional diversity of calcium signaling in the mouse and human brain.iScience · 2026Article
- Transcriptional and epigenetic regulation of CaBioinformatics advances · 2026Article
- CaAmerican journal of physiology. Cell physiology · 2025Article
- Transcriptional reprogramming in SMA mouse hearts reveals signatures of early heart failure and dysregulated calcium signaling.Human molecular genetics · 2025Article
- Regulation of formin INF2 and its alteration in INF2-linked inherited disorders.Cellular and molecular life sciences : CMLS · 2024Review
- A pleiotropic recurrent dominantScience advances · 2024Article
- Article
- Compartments in medulloblastoma with extensive nodularity are connected through differentiation along the granular precursor lineage.Nature communications · 2024Article
- Editorial: Current proceedings in magnetocardiology-past, present, future.Frontiers in cardiovascular medicine · 2024Article
- Transcriptional regulation in the absence of inositol trisphosphate receptor calcium signaling.Frontiers in cell and developmental biology · 2024Article
- Expression and associated epigenetic mechanisms of the CaJournal of cell communication and signaling · 2022Article
- DisruptedProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Article
- Angelman Syndrome and Angelman-like Syndromes Share the Same Calcium-Related Gene Signatures.International journal of molecular sciences · 2021Article
- Transcriptional and epigenetic landscape of CaJournal of cell communication and signaling · 2021Article
- Gene-set Enrichment with Mathematical Biology (GEMB).GigaScience · 2020Article
- Interplay between morphogen-directed positional information systems and physiological signaling.Developmental dynamics : an official publication of the American Association of Anatomists · 2020Review
- Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
motivationSignal transduction via calcium ions (Ca2+) represents a fundamental signaling pathway in all eukaryotic cells. A large portion of the human genome encodes proteins used to assemble signaling systems that can transduce signals with diverse spatial and temporal dynamics.
resultsHere, we provide a map of all of the genes involved in Ca2+ signaling and link these genes to human genetic disorders. Using Gene Ontology terms and genome databases, 1805 genes were identified as regulators or targets of intracellular Ca2+ signals. Associating these 1805 genes with human genetic disorders uncovered 1470 diseases with mutated 'Ca2+ genes'. A network with scale-free properties appeared when the Ca2+ genes were mapped to their associated genetic disorders. AVAILABILITY AND IMPLEMENTATION: The Ca2+ genome database is freely available at http://cagedb.uhlenlab.org and will foster studies of gene functions and genetic disorders associated with Ca2+ signaling. CONTACT: per.uhlen@ki.se. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.
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